Abnormal keratin expression in circumscribed palmar hypokeratosis

Akira Ishiko, Itaru Dekio, Atsushi Fujimoto, Kaori Kameyama, Mitsuo Sakamoto, Yoshimi Benno, Masayuki Amagai, Takeji Nishikawa

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume57
Issue number2
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

Fingerprint

Dermoscopy
Keratins
Keratin-2
Keratin-16
Microbial Genes
Immunohistochemistry
Immersion
Erythema
rRNA Genes
Anti-Idiotypic Antibodies
Electron Microscopy
Cytoplasm
Observation
Staining and Labeling
Bacteria
Polymerase Chain Reaction
Skin
Antibodies
DNA

ASJC Scopus subject areas

  • Dermatology

Cite this

Abnormal keratin expression in circumscribed palmar hypokeratosis. / Ishiko, Akira; Dekio, Itaru; Fujimoto, Atsushi; Kameyama, Kaori; Sakamoto, Mitsuo; Benno, Yoshimi; Amagai, Masayuki; Nishikawa, Takeji.

In: Journal of the American Academy of Dermatology, Vol. 57, No. 2, 08.2007, p. 285-291.

Research output: Contribution to journalArticle

Ishiko, Akira ; Dekio, Itaru ; Fujimoto, Atsushi ; Kameyama, Kaori ; Sakamoto, Mitsuo ; Benno, Yoshimi ; Amagai, Masayuki ; Nishikawa, Takeji. / Abnormal keratin expression in circumscribed palmar hypokeratosis. In: Journal of the American Academy of Dermatology. 2007 ; Vol. 57, No. 2. pp. 285-291.
@article{46abf07610f24a7ca3f1e05fae8e0524,
title = "Abnormal keratin expression in circumscribed palmar hypokeratosis",
abstract = "Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.",
author = "Akira Ishiko and Itaru Dekio and Atsushi Fujimoto and Kaori Kameyama and Mitsuo Sakamoto and Yoshimi Benno and Masayuki Amagai and Takeji Nishikawa",
year = "2007",
month = "8",
doi = "10.1016/j.jaad.2007.02.035",
language = "English",
volume = "57",
pages = "285--291",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Abnormal keratin expression in circumscribed palmar hypokeratosis

AU - Ishiko, Akira

AU - Dekio, Itaru

AU - Fujimoto, Atsushi

AU - Kameyama, Kaori

AU - Sakamoto, Mitsuo

AU - Benno, Yoshimi

AU - Amagai, Masayuki

AU - Nishikawa, Takeji

PY - 2007/8

Y1 - 2007/8

N2 - Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.

AB - Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.

UR - http://www.scopus.com/inward/record.url?scp=34447261866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447261866&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2007.02.035

DO - 10.1016/j.jaad.2007.02.035

M3 - Article

VL - 57

SP - 285

EP - 291

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 2

ER -