TY - JOUR
T1 - Abnormal keratin expression in circumscribed palmar hypokeratosis
AU - Ishiko, Akira
AU - Dekio, Itaru
AU - Fujimoto, Atsushi
AU - Kameyama, Kaori
AU - Sakamoto, Mitsuo
AU - Benno, Yoshimi
AU - Amagai, Masayuki
AU - Nishikawa, Takeji
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.
AB - Background: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described. Objective: To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases. Methods: Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted. Results: Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected. Limitations: The number of cases analyzed was two. Conclusion: Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.
UR - http://www.scopus.com/inward/record.url?scp=34447261866&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447261866&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2007.02.035
DO - 10.1016/j.jaad.2007.02.035
M3 - Article
C2 - 17553594
AN - SCOPUS:34447261866
VL - 57
SP - 285
EP - 291
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 2
ER -