Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease

K. Yamaguchi, Masaaki Mori, A. Kawai, T. Takasugi, E. Koda, T. Aoki, K. Suzuki, A. Miyata, K. Nishio, Y. Suzuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To assess whether diffusion-limited gas exchange plays a significant role in hypoxemia in various types of chronic obstructive pulmonary disease (COPD), we analyzed the distribution of ventilation-perfusion (V̇(Λ)/Q̇) ratios and of diffusing capacity-perfusion (G/Q̇) raiots. We compared V̇(Λ)/Q̇ and G/Q̇ distributions in patients with three basic types of COPD; emphysematous changes, bronchiolar involvement, and airway hypersecretion, which were classified based on symptoms and on findings of high resolution CT. The results were that 1) hypoxemia was not caused by diffusion-limited gas exchange with low G/Q̇ regions in any type of COPD, that 2) hypoxemia in COPD was caused by inhomogeneities in V̇(Λ)/Q̇ distribution, that 3) emphysematous changes and bronchial involvement were associated with high and low V̇(Λ)/Q̇ regions, respectively, and that 4) either hypersecretion itself or related airway abnormalities may cause low V̇(Λ)/Q̇ regions to form.

Original languageEnglish
Pages (from-to)856-863
Number of pages8
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number8
Publication statusPublished - 1996

Fingerprint

Ventilation-Perfusion Ratio
Chronic Obstructive Pulmonary Disease
Perfusion
Gases
Ventilation
Hypoxia

Keywords

  • Chronic obstructive pulmonary disease
  • Diffusing capacity-perfusion ratios
  • High-resolution CT
  • Ventilation- perfusion ratios

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease. / Yamaguchi, K.; Mori, Masaaki; Kawai, A.; Takasugi, T.; Koda, E.; Aoki, T.; Suzuki, K.; Miyata, A.; Nishio, K.; Suzuki, Y.

In: Japanese Journal of Thoracic Diseases, Vol. 34, No. 8, 1996, p. 856-863.

Research output: Contribution to journalArticle

Yamaguchi, K, Mori, M, Kawai, A, Takasugi, T, Koda, E, Aoki, T, Suzuki, K, Miyata, A, Nishio, K & Suzuki, Y 1996, 'Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease', Japanese Journal of Thoracic Diseases, vol. 34, no. 8, pp. 856-863.
Yamaguchi, K. ; Mori, Masaaki ; Kawai, A. ; Takasugi, T. ; Koda, E. ; Aoki, T. ; Suzuki, K. ; Miyata, A. ; Nishio, K. ; Suzuki, Y. / Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease. In: Japanese Journal of Thoracic Diseases. 1996 ; Vol. 34, No. 8. pp. 856-863.
@article{297681643b8c4ad0a694e84fc799a2e3,
title = "Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease",
abstract = "To assess whether diffusion-limited gas exchange plays a significant role in hypoxemia in various types of chronic obstructive pulmonary disease (COPD), we analyzed the distribution of ventilation-perfusion (V̇(Λ)/Q̇) ratios and of diffusing capacity-perfusion (G/Q̇) raiots. We compared V̇(Λ)/Q̇ and G/Q̇ distributions in patients with three basic types of COPD; emphysematous changes, bronchiolar involvement, and airway hypersecretion, which were classified based on symptoms and on findings of high resolution CT. The results were that 1) hypoxemia was not caused by diffusion-limited gas exchange with low G/Q̇ regions in any type of COPD, that 2) hypoxemia in COPD was caused by inhomogeneities in V̇(Λ)/Q̇ distribution, that 3) emphysematous changes and bronchial involvement were associated with high and low V̇(Λ)/Q̇ regions, respectively, and that 4) either hypersecretion itself or related airway abnormalities may cause low V̇(Λ)/Q̇ regions to form.",
keywords = "Chronic obstructive pulmonary disease, Diffusing capacity-perfusion ratios, High-resolution CT, Ventilation- perfusion ratios",
author = "K. Yamaguchi and Masaaki Mori and A. Kawai and T. Takasugi and E. Koda and T. Aoki and K. Suzuki and A. Miyata and K. Nishio and Y. Suzuki",
year = "1996",
language = "English",
volume = "34",
pages = "856--863",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "8",

}

TY - JOUR

T1 - Abnormalitis in the distributions of ventilation-perfusion ratios and diffusing capacity-perfusion ratios in three types of chronic obstructive pulmonary disease

AU - Yamaguchi, K.

AU - Mori, Masaaki

AU - Kawai, A.

AU - Takasugi, T.

AU - Koda, E.

AU - Aoki, T.

AU - Suzuki, K.

AU - Miyata, A.

AU - Nishio, K.

AU - Suzuki, Y.

PY - 1996

Y1 - 1996

N2 - To assess whether diffusion-limited gas exchange plays a significant role in hypoxemia in various types of chronic obstructive pulmonary disease (COPD), we analyzed the distribution of ventilation-perfusion (V̇(Λ)/Q̇) ratios and of diffusing capacity-perfusion (G/Q̇) raiots. We compared V̇(Λ)/Q̇ and G/Q̇ distributions in patients with three basic types of COPD; emphysematous changes, bronchiolar involvement, and airway hypersecretion, which were classified based on symptoms and on findings of high resolution CT. The results were that 1) hypoxemia was not caused by diffusion-limited gas exchange with low G/Q̇ regions in any type of COPD, that 2) hypoxemia in COPD was caused by inhomogeneities in V̇(Λ)/Q̇ distribution, that 3) emphysematous changes and bronchial involvement were associated with high and low V̇(Λ)/Q̇ regions, respectively, and that 4) either hypersecretion itself or related airway abnormalities may cause low V̇(Λ)/Q̇ regions to form.

AB - To assess whether diffusion-limited gas exchange plays a significant role in hypoxemia in various types of chronic obstructive pulmonary disease (COPD), we analyzed the distribution of ventilation-perfusion (V̇(Λ)/Q̇) ratios and of diffusing capacity-perfusion (G/Q̇) raiots. We compared V̇(Λ)/Q̇ and G/Q̇ distributions in patients with three basic types of COPD; emphysematous changes, bronchiolar involvement, and airway hypersecretion, which were classified based on symptoms and on findings of high resolution CT. The results were that 1) hypoxemia was not caused by diffusion-limited gas exchange with low G/Q̇ regions in any type of COPD, that 2) hypoxemia in COPD was caused by inhomogeneities in V̇(Λ)/Q̇ distribution, that 3) emphysematous changes and bronchial involvement were associated with high and low V̇(Λ)/Q̇ regions, respectively, and that 4) either hypersecretion itself or related airway abnormalities may cause low V̇(Λ)/Q̇ regions to form.

KW - Chronic obstructive pulmonary disease

KW - Diffusing capacity-perfusion ratios

KW - High-resolution CT

KW - Ventilation- perfusion ratios

UR - http://www.scopus.com/inward/record.url?scp=0029794836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029794836&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 856

EP - 863

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 8

ER -