ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation

for the donor/source working group of the Japan Society for Hematopoietic Cell Transplantation

Research output: Contribution to journalArticle

Abstract

The effects of ABO incompatibility on hematopoietic stem cell transplantation remain controversial. Large cohorts are required to obtain findings that allow for definite conclusions. We previously demonstrated poor overall survival and increased treatment-related mortality (TRM) in ABO-incompatible unrelated bone marrow transplantation (UR-BMT) performed during the period from 1993 to 2005. To improve our understanding of ABO-incompatible transplantation, we reanalyzed the effects of ABO mismatch in a UR-BMT cohort in Japan after 2000. Multivariate analyses for the 2000–2006 cohort showed that major ABO mismatch was associated with poor overall survival (HR, 1.211; 95% CI, 1.062 to 1.381; p = 0.004) and increased TRM (HR, 1.357; 95% CI, 1.146 to 1.608; p < 0.001). In the 2007–2015 cohort, major incompatibility had no effect on overall survival (HR, 0.987, p = 0.804) or TRM (HR, 1.020, p = 0.790). Delayed engraftment of erythrocytes, platelets, and neutrophils in cases of major mismatch was common between the two cohorts. In conclusion, the adverse effect of ABO major incompatibility has become less significant over time.

Original languageEnglish
JournalBone Marrow Transplantation
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Bone Marrow Transplantation
Mortality
Hematopoietic Stem Cell Transplantation
Japan
Neutrophils
Therapeutics
Blood Platelets
Multivariate Analysis
Transplantation
Erythrocytes

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation. / for the donor/source working group of the Japan Society for Hematopoietic Cell Transplantation.

In: Bone Marrow Transplantation, 01.01.2019.

Research output: Contribution to journalArticle

for the donor/source working group of the Japan Society for Hematopoietic Cell Transplantation. / ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation. In: Bone Marrow Transplantation. 2019.
@article{05ce1f6fc9ae4998b749fca98b622c22,
title = "ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation",
abstract = "The effects of ABO incompatibility on hematopoietic stem cell transplantation remain controversial. Large cohorts are required to obtain findings that allow for definite conclusions. We previously demonstrated poor overall survival and increased treatment-related mortality (TRM) in ABO-incompatible unrelated bone marrow transplantation (UR-BMT) performed during the period from 1993 to 2005. To improve our understanding of ABO-incompatible transplantation, we reanalyzed the effects of ABO mismatch in a UR-BMT cohort in Japan after 2000. Multivariate analyses for the 2000–2006 cohort showed that major ABO mismatch was associated with poor overall survival (HR, 1.211; 95{\%} CI, 1.062 to 1.381; p = 0.004) and increased TRM (HR, 1.357; 95{\%} CI, 1.146 to 1.608; p < 0.001). In the 2007–2015 cohort, major incompatibility had no effect on overall survival (HR, 0.987, p = 0.804) or TRM (HR, 1.020, p = 0.790). Delayed engraftment of erythrocytes, platelets, and neutrophils in cases of major mismatch was common between the two cohorts. In conclusion, the adverse effect of ABO major incompatibility has become less significant over time.",
author = "{for the donor/source working group of the Japan Society for Hematopoietic Cell Transplantation} and Fumihiko Kimura and Junya Kanda and Ken Ishiyama and Toshio Yabe and Kota Yoshifuji and Takahiro Fukuda and Yukiyasu Ozawa and Koji Iwato and Tetsuya Eto and Takehiko Mori and Naoyuki Uchida and Shuichi Ota and Toru Sakura and Tatsuo Ichinohe and Yoshiko Atsuta and Yoshinobu Kanda",
year = "2019",
month = "1",
day = "1",
doi = "10.1038/s41409-019-0496-2",
language = "English",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - ABO blood type incompatibility lost the unfavorable impact on outcome in unrelated bone marrow transplantation

AU - for the donor/source working group of the Japan Society for Hematopoietic Cell Transplantation

AU - Kimura, Fumihiko

AU - Kanda, Junya

AU - Ishiyama, Ken

AU - Yabe, Toshio

AU - Yoshifuji, Kota

AU - Fukuda, Takahiro

AU - Ozawa, Yukiyasu

AU - Iwato, Koji

AU - Eto, Tetsuya

AU - Mori, Takehiko

AU - Uchida, Naoyuki

AU - Ota, Shuichi

AU - Sakura, Toru

AU - Ichinohe, Tatsuo

AU - Atsuta, Yoshiko

AU - Kanda, Yoshinobu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The effects of ABO incompatibility on hematopoietic stem cell transplantation remain controversial. Large cohorts are required to obtain findings that allow for definite conclusions. We previously demonstrated poor overall survival and increased treatment-related mortality (TRM) in ABO-incompatible unrelated bone marrow transplantation (UR-BMT) performed during the period from 1993 to 2005. To improve our understanding of ABO-incompatible transplantation, we reanalyzed the effects of ABO mismatch in a UR-BMT cohort in Japan after 2000. Multivariate analyses for the 2000–2006 cohort showed that major ABO mismatch was associated with poor overall survival (HR, 1.211; 95% CI, 1.062 to 1.381; p = 0.004) and increased TRM (HR, 1.357; 95% CI, 1.146 to 1.608; p < 0.001). In the 2007–2015 cohort, major incompatibility had no effect on overall survival (HR, 0.987, p = 0.804) or TRM (HR, 1.020, p = 0.790). Delayed engraftment of erythrocytes, platelets, and neutrophils in cases of major mismatch was common between the two cohorts. In conclusion, the adverse effect of ABO major incompatibility has become less significant over time.

AB - The effects of ABO incompatibility on hematopoietic stem cell transplantation remain controversial. Large cohorts are required to obtain findings that allow for definite conclusions. We previously demonstrated poor overall survival and increased treatment-related mortality (TRM) in ABO-incompatible unrelated bone marrow transplantation (UR-BMT) performed during the period from 1993 to 2005. To improve our understanding of ABO-incompatible transplantation, we reanalyzed the effects of ABO mismatch in a UR-BMT cohort in Japan after 2000. Multivariate analyses for the 2000–2006 cohort showed that major ABO mismatch was associated with poor overall survival (HR, 1.211; 95% CI, 1.062 to 1.381; p = 0.004) and increased TRM (HR, 1.357; 95% CI, 1.146 to 1.608; p < 0.001). In the 2007–2015 cohort, major incompatibility had no effect on overall survival (HR, 0.987, p = 0.804) or TRM (HR, 1.020, p = 0.790). Delayed engraftment of erythrocytes, platelets, and neutrophils in cases of major mismatch was common between the two cohorts. In conclusion, the adverse effect of ABO major incompatibility has become less significant over time.

UR - http://www.scopus.com/inward/record.url?scp=85062940976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062940976&partnerID=8YFLogxK

U2 - 10.1038/s41409-019-0496-2

DO - 10.1038/s41409-019-0496-2

M3 - Article

C2 - 30867557

AN - SCOPUS:85062940976

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

ER -