Absence of association of α1-antichymotrypsin polymorphisms with Alzheimer's disease: A report on autopsy-confirmed cases

Shigeru Itabashi; Hiroyuki Arai; Toshifumi Matsui; Sachio Matsushita; Taro Muramatsu; Susumu Higuchi; John Q. Trojanowski; Hidetada Sasaki

doi:10.1006/exnr.1998.6802

Absence of association of α₁-antichymotrypsin polymorphisms with Alzheimer's disease: A report on autopsy-confirmed cases

Shigeru Itabashi, Hiroyuki Arai, Toshifumi Matsui, Sachio Matsushita, Taro Muramatsu, Susumu Higuchi, John Q. Trojanowski, Hidetada Sasaki

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

α₁-Antichymotrypsin (ACT) polymorphisms were examined in 79 cases with autopsy-confirmed Alzheimer's disease (AD) as well as in 28 cases with autopsy-confirmed nonneurological diseases to test the hypothesis that ACT polymorphisms confer a risk to an individual to develop AD. Neither ACT genotype frequency nor ACT allele frequency in the AD group was significantly different from the control group. The ACT polymorphic pattern was essentially the same among apolipoprotein E (apoE) ε4 carriers and noncarriers. The age at onset of AD was not significantly affected by the inherited dose of ACT/A allele. Taking together, our observations do not confirm the effect of the ACT/A allele as a risk factor for developing AD in addition to the ApoE ε4 allele.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Experimental Neurology
Volume	151
Issue number	2
DOIs	https://doi.org/10.1006/exnr.1998.6802
Publication status	Published - 1998 Jun
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E
Autopsy- confirmed
Polymorphism
α-Antichymotrypsin

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1006/exnr.1998.6802

Cite this

@article{68b53fd945b041619ee5b61c3840e8a4,

title = "Absence of association of α1-antichymotrypsin polymorphisms with Alzheimer's disease: A report on autopsy-confirmed cases",

abstract = "α1-Antichymotrypsin (ACT) polymorphisms were examined in 79 cases with autopsy-confirmed Alzheimer's disease (AD) as well as in 28 cases with autopsy-confirmed nonneurological diseases to test the hypothesis that ACT polymorphisms confer a risk to an individual to develop AD. Neither ACT genotype frequency nor ACT allele frequency in the AD group was significantly different from the control group. The ACT polymorphic pattern was essentially the same among apolipoprotein E (apoE) ε4 carriers and noncarriers. The age at onset of AD was not significantly affected by the inherited dose of ACT/A allele. Taking together, our observations do not confirm the effect of the ACT/A allele as a risk factor for developing AD in addition to the ApoE ε4 allele.",

keywords = "Alzheimer's disease, Apolipoprotein E, Autopsy- confirmed, Polymorphism, α-Antichymotrypsin",

author = "Shigeru Itabashi and Hiroyuki Arai and Toshifumi Matsui and Sachio Matsushita and Taro Muramatsu and Susumu Higuchi and Trojanowski, {John Q.} and Hidetada Sasaki",

year = "1998",

month = jun,

doi = "10.1006/exnr.1998.6802",

language = "English",

volume = "151",

pages = "237--240",

journal = "Neurodegeneration",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Absence of association of α1-antichymotrypsin polymorphisms with Alzheimer's disease

T2 - A report on autopsy-confirmed cases

AU - Itabashi, Shigeru

AU - Arai, Hiroyuki

AU - Matsui, Toshifumi

AU - Matsushita, Sachio

AU - Muramatsu, Taro

AU - Higuchi, Susumu

AU - Trojanowski, John Q.

AU - Sasaki, Hidetada

PY - 1998/6

Y1 - 1998/6

N2 - α1-Antichymotrypsin (ACT) polymorphisms were examined in 79 cases with autopsy-confirmed Alzheimer's disease (AD) as well as in 28 cases with autopsy-confirmed nonneurological diseases to test the hypothesis that ACT polymorphisms confer a risk to an individual to develop AD. Neither ACT genotype frequency nor ACT allele frequency in the AD group was significantly different from the control group. The ACT polymorphic pattern was essentially the same among apolipoprotein E (apoE) ε4 carriers and noncarriers. The age at onset of AD was not significantly affected by the inherited dose of ACT/A allele. Taking together, our observations do not confirm the effect of the ACT/A allele as a risk factor for developing AD in addition to the ApoE ε4 allele.

AB - α1-Antichymotrypsin (ACT) polymorphisms were examined in 79 cases with autopsy-confirmed Alzheimer's disease (AD) as well as in 28 cases with autopsy-confirmed nonneurological diseases to test the hypothesis that ACT polymorphisms confer a risk to an individual to develop AD. Neither ACT genotype frequency nor ACT allele frequency in the AD group was significantly different from the control group. The ACT polymorphic pattern was essentially the same among apolipoprotein E (apoE) ε4 carriers and noncarriers. The age at onset of AD was not significantly affected by the inherited dose of ACT/A allele. Taking together, our observations do not confirm the effect of the ACT/A allele as a risk factor for developing AD in addition to the ApoE ε4 allele.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Autopsy- confirmed

KW - Polymorphism

KW - α-Antichymotrypsin

UR - http://www.scopus.com/inward/record.url?scp=0032081298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032081298&partnerID=8YFLogxK

U2 - 10.1006/exnr.1998.6802

DO - 10.1006/exnr.1998.6802

M3 - Article

C2 - 9628759

AN - SCOPUS:0032081298

SN - 0014-4886

VL - 151

SP - 237

EP - 240

JO - Neurodegeneration

JF - Neurodegeneration

IS - 2

ER -