Absence of germline CHK2 mutations in familial gastric cancer

Kenji Kimura, Kazuya Shinmura, Kimio Yoshimura, Kimihiro Shimizu, Hitoshi Katai, Yasuo Beppu, Hideshige Moriya, Jun Yokota

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recently, the CHK2 gene was identified as being a candidate gene responsible for Li-Fraumeni syndrome (LFS). Gastric cancer is often clustered in families with LFS, so it is possible that germline CHK2 mutation is also present in familial gastric cancer (FGC). We therefore defined the genomic structure of the CHK2 gene, designed intronic primers, and searched for germline CHK2 mutations in 25 FGC cases by polymerase chain reaction-single strand conformational polymorphism analysis of the entire coding region. In all of the 25 cases, at least two siblings had histories of gastric cancer. There were no FGC cases that showed germline CHK2 mutations. Thus, it was indicated that germline CHK2 mutations do not contribute to the familial clustering of gastric cancer.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
JournalJapanese Journal of Cancer Research
Volume91
Issue number9
DOIs
Publication statusPublished - 2000

Keywords

  • CHK2
  • Familial gastric cancer
  • Germline mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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