Absent circadian variation of blood pressure in patients with anorexia nervosa

Midori Awazu, Seiji Matsuoka, Tsutomu Kamimaki, Hisako Watanabe, Nobutake Matsuo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To examine whether circadian rhythm of blood pressure (BP) is altered in patients with anorexia nervosa (AN), and if so, to determine whether it is reversible after refeeding. Study design: Ambulatory BP monitoring was performed on 17 female inpatients with AN (mean age, 13.3 ± 1.9 years) at the time of admission and serially during refeeding; 17 age- matched normal weight, normotensive female inpatients served as control subjects. Results: Patients with AN had lost an average of 23.4% ± 11.5% of body weight before the illness. Weight after refeeding was 105.6% ± 9.2% of that before illness. Mean 24-hour systolic BP (SBP) (96.5 ± 8.6 mm Hg) and diastolic BP (DBP) (53.4 ± 5.8 mm Hg) were significantly lower in patients with AN compared with those of control subjects (SBP, 106.1 ± 6.5 mm Hg; DBP, 60.2 ± 5.8 mm Hg). Although awake SBP and DBP were also lower in patients with AN, asleep SBP and DBP were not statistically different from those of control subjects. Night/day BP ratio in the control group was 0.93 ± 0.06 in systolic and 0.92 ± 0.09 in diastolic. Those values were significantly elevated in patients with AN (systolic 1.00 ± 0.09 and diastolic 1.00 ± 0.09). After refeeding, the ratio decreased to 0.88 ± 0.09 and 0.90 ± 0.08, respectively (both P < .05 vs baseline). Conclusions: In patients with AN, circadian variation of BP is absent. This reverts to normal after refeeding.

Original languageEnglish
Pages (from-to)524-527
Number of pages4
JournalJournal of Pediatrics
Volume136
Issue number4
Publication statusPublished - 2000

Fingerprint

Anorexia Nervosa
Blood Pressure
Inpatients
Weights and Measures
Ambulatory Blood Pressure Monitoring
Circadian Rhythm
Body Weight
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Awazu, M., Matsuoka, S., Kamimaki, T., Watanabe, H., & Matsuo, N. (2000). Absent circadian variation of blood pressure in patients with anorexia nervosa. Journal of Pediatrics, 136(4), 524-527.

Absent circadian variation of blood pressure in patients with anorexia nervosa. / Awazu, Midori; Matsuoka, Seiji; Kamimaki, Tsutomu; Watanabe, Hisako; Matsuo, Nobutake.

In: Journal of Pediatrics, Vol. 136, No. 4, 2000, p. 524-527.

Research output: Contribution to journalArticle

Awazu, M, Matsuoka, S, Kamimaki, T, Watanabe, H & Matsuo, N 2000, 'Absent circadian variation of blood pressure in patients with anorexia nervosa', Journal of Pediatrics, vol. 136, no. 4, pp. 524-527.
Awazu M, Matsuoka S, Kamimaki T, Watanabe H, Matsuo N. Absent circadian variation of blood pressure in patients with anorexia nervosa. Journal of Pediatrics. 2000;136(4):524-527.
Awazu, Midori ; Matsuoka, Seiji ; Kamimaki, Tsutomu ; Watanabe, Hisako ; Matsuo, Nobutake. / Absent circadian variation of blood pressure in patients with anorexia nervosa. In: Journal of Pediatrics. 2000 ; Vol. 136, No. 4. pp. 524-527.
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N2 - Objective: To examine whether circadian rhythm of blood pressure (BP) is altered in patients with anorexia nervosa (AN), and if so, to determine whether it is reversible after refeeding. Study design: Ambulatory BP monitoring was performed on 17 female inpatients with AN (mean age, 13.3 ± 1.9 years) at the time of admission and serially during refeeding; 17 age- matched normal weight, normotensive female inpatients served as control subjects. Results: Patients with AN had lost an average of 23.4% ± 11.5% of body weight before the illness. Weight after refeeding was 105.6% ± 9.2% of that before illness. Mean 24-hour systolic BP (SBP) (96.5 ± 8.6 mm Hg) and diastolic BP (DBP) (53.4 ± 5.8 mm Hg) were significantly lower in patients with AN compared with those of control subjects (SBP, 106.1 ± 6.5 mm Hg; DBP, 60.2 ± 5.8 mm Hg). Although awake SBP and DBP were also lower in patients with AN, asleep SBP and DBP were not statistically different from those of control subjects. Night/day BP ratio in the control group was 0.93 ± 0.06 in systolic and 0.92 ± 0.09 in diastolic. Those values were significantly elevated in patients with AN (systolic 1.00 ± 0.09 and diastolic 1.00 ± 0.09). After refeeding, the ratio decreased to 0.88 ± 0.09 and 0.90 ± 0.08, respectively (both P < .05 vs baseline). Conclusions: In patients with AN, circadian variation of BP is absent. This reverts to normal after refeeding.

AB - Objective: To examine whether circadian rhythm of blood pressure (BP) is altered in patients with anorexia nervosa (AN), and if so, to determine whether it is reversible after refeeding. Study design: Ambulatory BP monitoring was performed on 17 female inpatients with AN (mean age, 13.3 ± 1.9 years) at the time of admission and serially during refeeding; 17 age- matched normal weight, normotensive female inpatients served as control subjects. Results: Patients with AN had lost an average of 23.4% ± 11.5% of body weight before the illness. Weight after refeeding was 105.6% ± 9.2% of that before illness. Mean 24-hour systolic BP (SBP) (96.5 ± 8.6 mm Hg) and diastolic BP (DBP) (53.4 ± 5.8 mm Hg) were significantly lower in patients with AN compared with those of control subjects (SBP, 106.1 ± 6.5 mm Hg; DBP, 60.2 ± 5.8 mm Hg). Although awake SBP and DBP were also lower in patients with AN, asleep SBP and DBP were not statistically different from those of control subjects. Night/day BP ratio in the control group was 0.93 ± 0.06 in systolic and 0.92 ± 0.09 in diastolic. Those values were significantly elevated in patients with AN (systolic 1.00 ± 0.09 and diastolic 1.00 ± 0.09). After refeeding, the ratio decreased to 0.88 ± 0.09 and 0.90 ± 0.08, respectively (both P < .05 vs baseline). Conclusions: In patients with AN, circadian variation of BP is absent. This reverts to normal after refeeding.

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