Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man

Yusuke Tanigawara; Kiyoshi Yamaoka; Terumichi Nakagawa; Toyozo Uno

doi:10.1248/cpb.30.2174

Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5, 1.0, and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.

Original language	English
Pages (from-to)	2174-2180
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	30
Issue number	6
DOIs	https://doi.org/10.1248/cpb.30.2174
Publication status	Published - 1982
Externally published	Yes

Keywords

capacity-limited absorption
carbenicillin
carbenicillin indanyl
carbenicillin phenyl
mean absorption time
moment analysis

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.30.2174

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title = "Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man",

abstract = "Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5, 1.0, and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.",

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year = "1982",

doi = "10.1248/cpb.30.2174",

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pages = "2174--2180",

journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man

AU - Tanigawara, Yusuke

AU - Yamaoka, Kiyoshi

AU - Nakagawa, Terumichi

AU - Uno, Toyozo

PY - 1982

Y1 - 1982

N2 - Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5, 1.0, and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.

AB - Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5, 1.0, and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.

KW - capacity-limited absorption

KW - carbenicillin

KW - carbenicillin indanyl

KW - carbenicillin phenyl

KW - mean absorption time

KW - moment analysis

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Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man

Abstract

Keywords

ASJC Scopus subject areas

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