Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man

Yusuke Tanigawara, Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5, 1.0, and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.

Original languageEnglish
Pages (from-to)2174-2180
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume30
Issue number6
DOIs
Publication statusPublished - 1982 Jan 1
Externally publishedYes

Keywords

  • capacity-limited absorption
  • carbenicillin
  • carbenicillin indanyl
  • carbenicillin phenyl
  • mean absorption time
  • moment analysis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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