Acarbose, an α-glucosidase inhibitor, decreases aortic gene expression and serum levels of monocyte chemoattractant protein-1 in fructose-fed rats

K. Nakamura, Shoichi Yamagishi, T. Matsui, T. Yoshida, T. Imaizumi, T. Makino, T. Shimizu, H. Inoue

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin resistance is one of the determinants of post-prandial hyperglycaemia. Recently, acarbose, an α-glucosidase inhibitor that delays the absorption of carbohydrates from the small intestine, has been found to reduce the incidence of cardiovascular disease in patients with impaired glucose tolerance or diabetes. However, the molecular mechanism by which acarbose inhibits cardiovascular events remains unknown. In this study, we examined whether oral administration of acarbose could suppress expression of monocyte chemoattractant protein-1 (MCP-1) in fructose-fed rats, a widely used animal model of insulin resistance. Serum MCP-1 levels were elevated in fructose-fed rats after 4 weeks. Acarbose treatment for 4 weeks reduced the fructose-induced elevation of serum MCP-1 levels. Acarbose treatment for 8 weeks decreased MCP-1 mRNA levels in the aortae of fructose-fed rats. These results suggest that the cardioprotective effects of acarbose could be due, at least in part, to the suppression of MCP-1 expression.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalJournal of International Medical Research
Volume34
Issue number5
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes

Keywords

  • Acarbose
  • Antidiabetic agent
  • Atherosclerosis
  • Cardiovascular disease
  • Diabetes
  • Insulin resistance
  • Monocyte chemoattractant protein-1 (MCP-1)
  • Post-prandial hyperglycaemia

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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