Accelerated glycosylation under frozen conditions

Maki Takatani; Jun Nakano; Midori A. Arai; Akihiro Ishiwata; Hiromichi Ohta; Yukishige Ito

doi:10.1016/j.tetlet.2004.03.100

Accelerated glycosylation under frozen conditions

Maki Takatani, Jun Nakano, Midori A. Arai, Akihiro Ishiwata, Hiromichi Ohta, Yukishige Ito

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

O-Glycosylations using thiomethyl glycosides as donors were compared under both frozen and unfrozen conditions. In the presence of MeOTf as a promoter, enormous rate acceleration was observed when the glycosylation was conducted in p-xylene below its freezing point.

Original language	English
Pages (from-to)	3929-3932
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	20
DOIs	https://doi.org/10.1016/j.tetlet.2004.03.100
Publication status	Published - 2004 May 10
Externally published	Yes

Keywords

Frozen
Glycosylation
High-mannose type
Oligosaccharide
Rate acceleration

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.03.100

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title = "Accelerated glycosylation under frozen conditions",

abstract = "O-Glycosylations using thiomethyl glycosides as donors were compared under both frozen and unfrozen conditions. In the presence of MeOTf as a promoter, enormous rate acceleration was observed when the glycosylation was conducted in p-xylene below its freezing point.",

keywords = "Frozen, Glycosylation, High-mannose type, Oligosaccharide, Rate acceleration",

author = "Maki Takatani and Jun Nakano and Arai, {Midori A.} and Akihiro Ishiwata and Hiromichi Ohta and Yukishige Ito",

note = "Funding Information: Financial support from a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Grant no. 13480191) is acknowledged with thanks. M.A.A. is a Basic Science Special Postdoctoral Fellow of RIKEN. The authors thank Ms. Akemi Takahashi for technical assistance. ",

year = "2004",

month = may,

day = "10",

doi = "10.1016/j.tetlet.2004.03.100",

language = "English",

volume = "45",

pages = "3929--3932",

journal = "Tetrahedron Letters",

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T1 - Accelerated glycosylation under frozen conditions

AU - Takatani, Maki

AU - Nakano, Jun

AU - Arai, Midori A.

AU - Ishiwata, Akihiro

AU - Ohta, Hiromichi

AU - Ito, Yukishige

N1 - Funding Information: Financial support from a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Grant no. 13480191) is acknowledged with thanks. M.A.A. is a Basic Science Special Postdoctoral Fellow of RIKEN. The authors thank Ms. Akemi Takahashi for technical assistance.

PY - 2004/5/10

Y1 - 2004/5/10

N2 - O-Glycosylations using thiomethyl glycosides as donors were compared under both frozen and unfrozen conditions. In the presence of MeOTf as a promoter, enormous rate acceleration was observed when the glycosylation was conducted in p-xylene below its freezing point.

AB - O-Glycosylations using thiomethyl glycosides as donors were compared under both frozen and unfrozen conditions. In the presence of MeOTf as a promoter, enormous rate acceleration was observed when the glycosylation was conducted in p-xylene below its freezing point.

KW - Frozen

KW - Glycosylation

KW - High-mannose type

KW - Oligosaccharide

KW - Rate acceleration

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DO - 10.1016/j.tetlet.2004.03.100

M3 - Article

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SN - 0040-4039

VL - 45

SP - 3929

EP - 3932

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 20

ER -

Accelerated glycosylation under frozen conditions

Abstract

Keywords

ASJC Scopus subject areas

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