Accelerated glycosylation under frozen conditions

Maki Takatani, Jun Nakano, Midori A. Arai, Akihiro Ishiwata, Hiromichi Ohta, Yukishige Ito

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

O-Glycosylations using thiomethyl glycosides as donors were compared under both frozen and unfrozen conditions. In the presence of MeOTf as a promoter, enormous rate acceleration was observed when the glycosylation was conducted in p-xylene below its freezing point.

Original languageEnglish
Pages (from-to)3929-3932
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number20
DOIs
Publication statusPublished - 2004 May 10
Externally publishedYes

Keywords

  • Frozen
  • Glycosylation
  • High-mannose type
  • Oligosaccharide
  • Rate acceleration

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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