Accelerating progress in induced pluripotent stem cell research for neurological diseases

Daisuke Ito, Hideyuki Okano, Norihiro Suzuki

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In 2006, Yamanaka's group pioneered a method for reprogramming somatic cells by introducing definite transcription factors, which enabled the generation of induced pluripotent stem cells (iPSCs) with pluripotency comparable to that of embryonic stem cells. These iPSCs are attracting considerable attention for their potential in rejection-tolerance personalized replacement therapy. In recent years, patient-derived iPSCs have been used to recapitulate the phenotypes of neurological diseases and broaden our understanding of the pathogenesis of many neurological diseases, including those of late onset. It is now expected that iPSCs will serve as an unlimited source of disease-specific neural cells for use in disease modeling. This review outlines current progress in neurodegenerative disease research involving iPSCs and discusses the potential roles iPSCs may play in helping researchers elucidate the pathological processes of neurodegenerative diseases and in drug discovery and regenerative medicine.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalAnnals of Neurology
Volume72
Issue number2
DOIs
Publication statusPublished - 2012 Aug 1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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