Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer

Akimichi Shibata, Shuhei Yada, Naonari Kondo, Mitsuhiro Terakawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biodegradability is a key property of biodegradable polymers for tissue scaffold applications. Among the methods to control biodegradability, laser processing is a simple technique, which enables the alteration of biodegradability even after molding. Since ultrafast laser processing realizes precise processing of biodegradable polymer with less heat affected zone, ultrafast laser processing has the potential to fabricate tissue scaffolds and to control its biodegradability. In this study, we investigate the effect of femtosecond laser wavelength on the biodegradability of PLGA. We evaluated the biodegradability of PLGA irradiated with femtosecond laser pulses at the wavelength of 800, 400, 266 nm by the measurement of the change in mass of PLGA during water immersion. The results of degradation tests indicate that PLGA irradiated with the shorter wavelength show faster water absorption as well as rapid mass decrease. Since the results of X-ray photoelectron spectroscopy analysis indicate that the chemical bonds of PLGA irradiated with the shorter wavelength are dissociated more significantly, the acceleration of the biodegradation could be attributable to the decrease in molecular weight by chemical bond breaking.

Original languageEnglish
Title of host publicationFrontiers in Ultrafast Optics
Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVII
EditorsPeter R. Herman, Alexander Heisterkamp, Michel Meunier, Roberto Osellame
PublisherSPIE
ISBN (Electronic)9781510606296
DOIs
Publication statusPublished - 2017
EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017 - San Francisco, United States
Duration: 2017 Jan 292017 Feb 2

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10094
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017
CountryUnited States
CitySan Francisco
Period17/1/2917/2/2

Keywords

  • Biodegradable
  • Femtosecond laser
  • PLGA
  • Polymer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Shibata, A., Yada, S., Kondo, N., & Terakawa, M. (2017). Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer. In P. R. Herman, A. Heisterkamp, M. Meunier, & R. Osellame (Eds.), Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII [100941T] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10094). SPIE. https://doi.org/10.1117/12.2250028