Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer

Akimichi Shibata, Shuhei Yada, Naonari Kondo, Mitsuhiro Terakawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Biodegradability is a key property of biodegradable polymers for tissue scaffold applications. Among the methods to control biodegradability, laser processing is a simple technique, which enables the alteration of biodegradability even after molding. Since ultrafast laser processing realizes precise processing of biodegradable polymer with less heat affected zone, ultrafast laser processing has the potential to fabricate tissue scaffolds and to control its biodegradability. In this study, we investigate the effect of femtosecond laser wavelength on the biodegradability of PLGA. We evaluated the biodegradability of PLGA irradiated with femtosecond laser pulses at the wavelength of 800, 400, 266 nm by the measurement of the change in mass of PLGA during water immersion. The results of degradation tests indicate that PLGA irradiated with the shorter wavelength show faster water absorption as well as rapid mass decrease. Since the results of X-ray photoelectron spectroscopy analysis indicate that the chemical bonds of PLGA irradiated with the shorter wavelength are dissociated more significantly, the acceleration of the biodegradation could be attributable to the decrease in molecular weight by chemical bond breaking.

    Original languageEnglish
    Title of host publicationFrontiers in Ultrafast Optics
    Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVII
    PublisherSPIE
    Volume10094
    ISBN (Electronic)9781510606296
    DOIs
    Publication statusPublished - 2017
    EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017 - San Francisco, United States
    Duration: 2017 Jan 292017 Feb 2

    Other

    OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017
    CountryUnited States
    CitySan Francisco
    Period17/1/2917/2/2

    Keywords

    • Biodegradable
    • Femtosecond laser
    • PLGA
    • Polymer

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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  • Cite this

    Shibata, A., Yada, S., Kondo, N., & Terakawa, M. (2017). Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer. In Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII (Vol. 10094). [100941T] SPIE. https://doi.org/10.1117/12.2250028