Access to Tetronic Acids via Silver-Catalyzed CO2 Incorporation into Conjugated Ynones

Yuta Sadamitsu, Keiichi Komatsuki, Kodai Saito, Tohru Yamada

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Facile and versatile access to highly functionalized tetronic acids has been successfully achieved through the reaction of conjugated ynones with carbon dioxide. In the presence of a base, the enolates generated from the ynones capture CO2 via a carbon-carbon bond-forming reaction, accompanied by a 5-exo-dig cyclization reaction of the resulting carboxylate to the alkyne, activated by a silver catalyst. The present method should be applicable to the synthesis of a wide variety of tetronic acids.

Original languageEnglish
Pages (from-to)3191-3194
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - 2017 Jun 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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