Microscopic mapping of accumulated photon-echo relaxation time, known as accumulated photon-echo imaging, has been developed as a new technique accessible to histological diagnosis. Photon-echo imaging for Rhodamine-stained tissue samples of human liver has been demonstrated by means of fluorescence detection of accumulated photon echo. In a liver tissue that included a moderately differentiated hepatocellular carcinoma, we obtained an accumulated photon-echo image that correlated with the histological diagnosis. However, for a liver tissue with a highly differentiated hepatocellular carcinoma, photon-echo imaging could not discriminate the carcinoma from a noncancerous liver tissue.
|Number of pages||8|
|Journal||Journal of the Optical Society of America B: Optical Physics|
|Publication status||Published - 1997 Apr|
ASJC Scopus subject areas
- Statistical and Nonlinear Physics
- Atomic and Molecular Physics, and Optics