Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery

M. Sagoh, Kazunari Yoshida, H. Wakamoto, H. Kamiguchi, M. Otani, R. Shiobara, S. Toya

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Perioperative nerve growth factor (NGF) levels in cerebrospinal fluid (CSF) of patients with acoustic neurinoma (14 cases), tentorial meningioma (1 case), or subarachnoid hemorrhage (1 case) were examined. Preoperative NGF levels in CSF were below the level of detection in all patients. However, NGF was found to accumulate transiently in CSF following neurosurgery. Pre- and postoperative CSF obtained from a patient with acoustic neurinoma enhanced the proliferation of astrocytes in neuronal cell cultures derived from embryonic rat cortex grown in serum-free defined medium, and increased choline acetyltransferase activity of cholinergic neurons derived from embryonic rat septal area and brainstem. The effect of postoperative CSF on septal and brainstem neurons was more potent than that of preoperative CSF. These results indicate that NGF and non-NGF-type neurotrophic activities accumulate in the CSF following neurosurgery. These neurotrophic activities are probably important in the regeneration of damaged neural networks in the central nervous system.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalNeurologia Medico-Chirurgica
Volume35
Issue number7
Publication statusPublished - 1995

Fingerprint

Neurosurgery
Nerve Growth Factor
Cerebrospinal Fluid
Acoustic Neuroma
Meningioma
Brain Stem
Septum of Brain
Cholinergic Neurons
Choline O-Acetyltransferase
Serum-Free Culture Media
Subarachnoid Hemorrhage
Astrocytes
Regeneration
Intercellular Signaling Peptides and Proteins
Central Nervous System
Cell Culture Techniques
Neurons

Keywords

  • acoustic neurinoma
  • astrocyte
  • cerebrospinal fluid
  • choline acetyltransferase
  • nerve growth factor
  • neurosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Sagoh, M., Yoshida, K., Wakamoto, H., Kamiguchi, H., Otani, M., Shiobara, R., & Toya, S. (1995). Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery. Neurologia Medico-Chirurgica, 35(7), 431-437.

Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery. / Sagoh, M.; Yoshida, Kazunari; Wakamoto, H.; Kamiguchi, H.; Otani, M.; Shiobara, R.; Toya, S.

In: Neurologia Medico-Chirurgica, Vol. 35, No. 7, 1995, p. 431-437.

Research output: Contribution to journalArticle

Sagoh, M, Yoshida, K, Wakamoto, H, Kamiguchi, H, Otani, M, Shiobara, R & Toya, S 1995, 'Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery', Neurologia Medico-Chirurgica, vol. 35, no. 7, pp. 431-437.
Sagoh, M. ; Yoshida, Kazunari ; Wakamoto, H. ; Kamiguchi, H. ; Otani, M. ; Shiobara, R. ; Toya, S. / Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery. In: Neurologia Medico-Chirurgica. 1995 ; Vol. 35, No. 7. pp. 431-437.
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