Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer

Kazuhiro Kitajima, Koji Murakami, Erena Yamasaki, Yasushi Kaji, Kazuro Sugimura

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The purpose is to evaluate the accuracy of integrated 18F- fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography ((CT) with intravenous contrast medium in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer, with surgical and histopathological findings used as the reference standard. Forty-five patients with endometrial or uterine cervical cancer underwent radical hysterectomy, including pelvic lymphadenectomy with or without paraaortic lymphadenectomy, after PET/CT. PET/CT findings were interpreted by two experienced radiologists in consensus. The criterion for malignancy on PET/CT images was increased tracer uptake by the lymph node, independent of node size. The overall node-based sensitivity, specificity, PPV, NPV and accuracy of PET/CT for detecting nodal metastases were 51.1% (23/45), 99.8% (1,927/1,931), 85.2% (23/27), 98.9% (1,927/1,949) and 98.7% (1,950/1,976), respectively. The sensitivity for detecting metastatic lesions 4 mm or less in short-axis diameter was 12.5% (2/16), that for between 5 and 9 mm was 66.7% (16/24), and that for 10 mm or larger was 100.0% (5/5). The overall patient-based sensitivity, specificity, positive predictive value ((PPV), negative predictive value (NPV), and accuracy were 50% (6/12), 90.9% (30/33), 66.7% (6/9), 83.3% (30/36) and 80.0% (36/45), respectively. Integrated FDG-PET/contrast-enhanced CT is superior to conventional imaging, but only moderately sensitive in predicting lymph node metastasis preoperatively in patients with uterine cancer.

Original languageEnglish
Pages (from-to)1529-1536
Number of pages8
JournalEuropean Radiology
Volume19
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Uterine Neoplasms
Positron-Emission Tomography
Lymph Nodes
Tomography
Neoplasm Metastasis
Lymph Node Excision
Sensitivity and Specificity
Fluorodeoxyglucose F18
Hysterectomy
Uterine Cervical Neoplasms
Contrast Media
Positron Emission Tomography Computed Tomography
Neoplasms

Keywords

  • FDG
  • Lymphnode metastasis
  • PET/CT
  • Uterine cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer. / Kitajima, Kazuhiro; Murakami, Koji; Yamasaki, Erena; Kaji, Yasushi; Sugimura, Kazuro.

In: European Radiology, Vol. 19, No. 6, 2009, p. 1529-1536.

Research output: Contribution to journalArticle

Kitajima, Kazuhiro ; Murakami, Koji ; Yamasaki, Erena ; Kaji, Yasushi ; Sugimura, Kazuro. / Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer. In: European Radiology. 2009 ; Vol. 19, No. 6. pp. 1529-1536.
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