Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine: The influence of diet

Fumiko Mashige, Yoshikazu Matsushima, Hideko Kanazawa, Ichiro Sakuma, Nobuharu Takai, Fumio Bessho, Akiyuki Ohkubo

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Concentrations of vanillylmandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), vanillic acid (VA) and 5-hydroxyindoleacetic acid (5-HIAA) in urine from healthy subjects were determined by a high-performance liquid chromatography system with a mixed-mode (C18/anion-exchange) column and an 8-channel electrochemical detector, in order to study the influence of diet, diurnal variation and age. The urinary excretion of 5-HIAA increased significantly after eating banana, pineapple, tomato, kiwi fruit and walnut. An increase in the urinary excretion of DOPAC and HVA after eating banana and that of VA after taking vanilla was also noted. The urinary excretion of VMA was not significantly influenced by any of the foods examined. The urinary excretion of 5-HIAA in the first-morning urine increased beyond the upper limit of the reference value when banana was taken at 2000 h the previous day. The excretion of all metabolites in the second-morning urine in the fasting state was within respective reference ranges. Diurnal variation of the excretion of VMA, DOPAC, HVA and 5-HIAA in urine was relatively small, but that of VA was large. The concentrations (mmol/mol creatinine) of VMA, DOPAC, HVA, 5-HIAA and VA in the first-morning urine from healthy subjects increased from 7 days after birth to 1 year and then decreased to adult levels at 13 years of age.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalAnnals of Clinical Biochemistry
Volume33
Issue number1
Publication statusPublished - 1996

Fingerprint

Hydroxyindoleacetic Acid
Vanilmandelic Acid
Vanillic Acid
Nutrition
Metabolites
Homovanillic Acid
Catecholamines
Musa
Urine
Diet
Acids
Healthy Volunteers
Reference Values
Eating
Vanilla
Ananas
Juglans
3,4-Dihydroxyphenylacetic Acid
High performance liquid chromatography
Lycopersicon esculentum

Keywords

  • 3,4-dihydroxyphenylacetic acid
  • Homovanillic acid
  • Vanillic acid
  • Vanillylmandelic acid

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Mashige, F., Matsushima, Y., Kanazawa, H., Sakuma, I., Takai, N., Bessho, F., & Ohkubo, A. (1996). Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine: The influence of diet. Annals of Clinical Biochemistry, 33(1), 43-49.

Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine : The influence of diet. / Mashige, Fumiko; Matsushima, Yoshikazu; Kanazawa, Hideko; Sakuma, Ichiro; Takai, Nobuharu; Bessho, Fumio; Ohkubo, Akiyuki.

In: Annals of Clinical Biochemistry, Vol. 33, No. 1, 1996, p. 43-49.

Research output: Contribution to journalArticle

Mashige, F, Matsushima, Y, Kanazawa, H, Sakuma, I, Takai, N, Bessho, F & Ohkubo, A 1996, 'Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine: The influence of diet', Annals of Clinical Biochemistry, vol. 33, no. 1, pp. 43-49.
Mashige, Fumiko ; Matsushima, Yoshikazu ; Kanazawa, Hideko ; Sakuma, Ichiro ; Takai, Nobuharu ; Bessho, Fumio ; Ohkubo, Akiyuki. / Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine : The influence of diet. In: Annals of Clinical Biochemistry. 1996 ; Vol. 33, No. 1. pp. 43-49.
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