TY - JOUR
T1 - Acoschimperoside P, 2′-acetate
T2 - A Hedgehog signaling inhibitory constituent from Vallaris glabra
AU - Rifai, Yusnita
AU - Arai, Midori A.
AU - Koyano, Takashi
AU - Kowithayakorn, Thaworn
AU - Ishibashi, Masami
N1 - Funding Information:
Acknowledgments We thank Drs. Fritz Aberger and Gerhard Regl (University of Salzburg) for the kind provision of tetracycline-regulated HaCaT cells, and Dr. Rune Toftgård (Karolinska Institute) for the 12GLIRE-TKO luciferase plasmid. This work was supported by a Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS).
PY - 2011/7
Y1 - 2011/7
N2 - Complete 1H and 13C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.
AB - Complete 1H and 13C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.
KW - Acoschimperoside P, 2′-acetate
KW - Hedgehog/GLI signaling inhibitors
KW - Vallaris glabra
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U2 - 10.1007/s11418-011-0530-1
DO - 10.1007/s11418-011-0530-1
M3 - Article
C2 - 21625949
AN - SCOPUS:79960465389
SN - 1861-0293
VL - 65
SP - 629
EP - 632
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
IS - 3-4
ER -
