Acoschimperoside P, 2′-acetate: A Hedgehog signaling inhibitory constituent from Vallaris glabra

Yusnita Rifai, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Complete 1H and 13C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalJournal of Natural Medicines
Volume65
Issue number3-4
DOIs
Publication statusPublished - 2011 Jul 1
Externally publishedYes

Keywords

  • Acoschimperoside P, 2′-acetate
  • Hedgehog/GLI signaling inhibitors
  • Vallaris glabra

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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