Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C

An international multicenter study

Ioan Sporea, Simona Bota, Markus Peck-Radosavljevic, Roxana Sirli, Hironori Tanaka, Hiroko Iijima, Radu Badea, Monica Lupsor, Carmen Fierbinteanu-Braticevici, Ana Petrisor, Hidetsugu Saito, Hirotoshi Ebinuma, Mireen Friedrich-Rust, Christoph Sarrazin, Hirokazu Takahashi, Naofumi Ono, Fabio Piscaglia, Alberto Borghi, Mirko D'Onofrio, Anna Gallotti & 3 others Arnulf Ferlitsch, Alina Popescu, Mirela Danila

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Aim: The aim of this international multicenter study was to evaluate the reliability of Acoustic Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with chronic hepatitis C. Patients and methods: We compared ARFI to liver biopsy (LB) in 914 patients (10 centers, 5 countries) with chronic hepatitis C. In each patient LB (evaluated according to the METAVIR score) and ARFI measurements were performed (median of 5-10 valid measurements, expressed in meters/second - m/s). In 400 from the 914 patients, transient elastography (TE) was also performed (median of 6-10 valid measurements, expressed in kiloPascals - kPa). Results: Valid ARFI measurements were obtained in 911 (99.6%) of 914 cases. On LB 61 cases (6.7%) had F0, 241 (26.4%) had F1, 202 (22.1%) had F2, 187 (20.4%) had F3, and 223 (24.4%) had F4 fibrosis. A highly significant correlation (r = 0.654) was found between ARFI measurements and fibrosis (p < 0.0001). The predictive values of ARFI for various stages of fibrosis were: F ≥ 1 - cut-off > 1.19 m/s (AUROC = 0.779), F ≥ 2 - cut-off > 1.33 m/s (AUROC = 0.792), F ≥ 3 - cut-off > 1.43 m/s (AUROC = 0.829), F = 4 - cut-off > 1.55 m/s (AUROC = 0.842). The correlation with histological fibrosis was not significantly different for TE in comparison with ARFI elastography: r = 0.728 vs. 0.689, p = 0.28. TE was better than ARFI for predicting the presence of liver cirrhosis (p = 0.01) and fibrosis (F ≥ 1, METAVIR) (p = 0.01). Conclusion: ARFI elastography is a reliable method for predicting fibrosis severity in chronic hepatitis C patients.

Original languageEnglish
Pages (from-to)4112-4118
Number of pages7
JournalEuropean Journal of Radiology
Volume81
Issue number12
DOIs
Publication statusPublished - 2012 Dec

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Elasticity Imaging Techniques
Chronic Hepatitis C
Acoustics
Multicenter Studies
Fibrosis
Radiation
Biopsy
Liver
Liver Cirrhosis

Keywords

  • Acoustic Radiation Force Impulse Elastography (ARFI)
  • Chronic hepatitis C
  • Liver fibrosis
  • Liver stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C : An international multicenter study. / Sporea, Ioan; Bota, Simona; Peck-Radosavljevic, Markus; Sirli, Roxana; Tanaka, Hironori; Iijima, Hiroko; Badea, Radu; Lupsor, Monica; Fierbinteanu-Braticevici, Carmen; Petrisor, Ana; Saito, Hidetsugu; Ebinuma, Hirotoshi; Friedrich-Rust, Mireen; Sarrazin, Christoph; Takahashi, Hirokazu; Ono, Naofumi; Piscaglia, Fabio; Borghi, Alberto; D'Onofrio, Mirko; Gallotti, Anna; Ferlitsch, Arnulf; Popescu, Alina; Danila, Mirela.

In: European Journal of Radiology, Vol. 81, No. 12, 12.2012, p. 4112-4118.

Research output: Contribution to journalArticle

Sporea, I, Bota, S, Peck-Radosavljevic, M, Sirli, R, Tanaka, H, Iijima, H, Badea, R, Lupsor, M, Fierbinteanu-Braticevici, C, Petrisor, A, Saito, H, Ebinuma, H, Friedrich-Rust, M, Sarrazin, C, Takahashi, H, Ono, N, Piscaglia, F, Borghi, A, D'Onofrio, M, Gallotti, A, Ferlitsch, A, Popescu, A & Danila, M 2012, 'Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study', European Journal of Radiology, vol. 81, no. 12, pp. 4112-4118. https://doi.org/10.1016/j.ejrad.2012.08.018
Sporea, Ioan ; Bota, Simona ; Peck-Radosavljevic, Markus ; Sirli, Roxana ; Tanaka, Hironori ; Iijima, Hiroko ; Badea, Radu ; Lupsor, Monica ; Fierbinteanu-Braticevici, Carmen ; Petrisor, Ana ; Saito, Hidetsugu ; Ebinuma, Hirotoshi ; Friedrich-Rust, Mireen ; Sarrazin, Christoph ; Takahashi, Hirokazu ; Ono, Naofumi ; Piscaglia, Fabio ; Borghi, Alberto ; D'Onofrio, Mirko ; Gallotti, Anna ; Ferlitsch, Arnulf ; Popescu, Alina ; Danila, Mirela. / Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C : An international multicenter study. In: European Journal of Radiology. 2012 ; Vol. 81, No. 12. pp. 4112-4118.
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T1 - Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C

T2 - An international multicenter study

AU - Sporea, Ioan

AU - Bota, Simona

AU - Peck-Radosavljevic, Markus

AU - Sirli, Roxana

AU - Tanaka, Hironori

AU - Iijima, Hiroko

AU - Badea, Radu

AU - Lupsor, Monica

AU - Fierbinteanu-Braticevici, Carmen

AU - Petrisor, Ana

AU - Saito, Hidetsugu

AU - Ebinuma, Hirotoshi

AU - Friedrich-Rust, Mireen

AU - Sarrazin, Christoph

AU - Takahashi, Hirokazu

AU - Ono, Naofumi

AU - Piscaglia, Fabio

AU - Borghi, Alberto

AU - D'Onofrio, Mirko

AU - Gallotti, Anna

AU - Ferlitsch, Arnulf

AU - Popescu, Alina

AU - Danila, Mirela

PY - 2012/12

Y1 - 2012/12

N2 - Aim: The aim of this international multicenter study was to evaluate the reliability of Acoustic Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with chronic hepatitis C. Patients and methods: We compared ARFI to liver biopsy (LB) in 914 patients (10 centers, 5 countries) with chronic hepatitis C. In each patient LB (evaluated according to the METAVIR score) and ARFI measurements were performed (median of 5-10 valid measurements, expressed in meters/second - m/s). In 400 from the 914 patients, transient elastography (TE) was also performed (median of 6-10 valid measurements, expressed in kiloPascals - kPa). Results: Valid ARFI measurements were obtained in 911 (99.6%) of 914 cases. On LB 61 cases (6.7%) had F0, 241 (26.4%) had F1, 202 (22.1%) had F2, 187 (20.4%) had F3, and 223 (24.4%) had F4 fibrosis. A highly significant correlation (r = 0.654) was found between ARFI measurements and fibrosis (p < 0.0001). The predictive values of ARFI for various stages of fibrosis were: F ≥ 1 - cut-off > 1.19 m/s (AUROC = 0.779), F ≥ 2 - cut-off > 1.33 m/s (AUROC = 0.792), F ≥ 3 - cut-off > 1.43 m/s (AUROC = 0.829), F = 4 - cut-off > 1.55 m/s (AUROC = 0.842). The correlation with histological fibrosis was not significantly different for TE in comparison with ARFI elastography: r = 0.728 vs. 0.689, p = 0.28. TE was better than ARFI for predicting the presence of liver cirrhosis (p = 0.01) and fibrosis (F ≥ 1, METAVIR) (p = 0.01). Conclusion: ARFI elastography is a reliable method for predicting fibrosis severity in chronic hepatitis C patients.

AB - Aim: The aim of this international multicenter study was to evaluate the reliability of Acoustic Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with chronic hepatitis C. Patients and methods: We compared ARFI to liver biopsy (LB) in 914 patients (10 centers, 5 countries) with chronic hepatitis C. In each patient LB (evaluated according to the METAVIR score) and ARFI measurements were performed (median of 5-10 valid measurements, expressed in meters/second - m/s). In 400 from the 914 patients, transient elastography (TE) was also performed (median of 6-10 valid measurements, expressed in kiloPascals - kPa). Results: Valid ARFI measurements were obtained in 911 (99.6%) of 914 cases. On LB 61 cases (6.7%) had F0, 241 (26.4%) had F1, 202 (22.1%) had F2, 187 (20.4%) had F3, and 223 (24.4%) had F4 fibrosis. A highly significant correlation (r = 0.654) was found between ARFI measurements and fibrosis (p < 0.0001). The predictive values of ARFI for various stages of fibrosis were: F ≥ 1 - cut-off > 1.19 m/s (AUROC = 0.779), F ≥ 2 - cut-off > 1.33 m/s (AUROC = 0.792), F ≥ 3 - cut-off > 1.43 m/s (AUROC = 0.829), F = 4 - cut-off > 1.55 m/s (AUROC = 0.842). The correlation with histological fibrosis was not significantly different for TE in comparison with ARFI elastography: r = 0.728 vs. 0.689, p = 0.28. TE was better than ARFI for predicting the presence of liver cirrhosis (p = 0.01) and fibrosis (F ≥ 1, METAVIR) (p = 0.01). Conclusion: ARFI elastography is a reliable method for predicting fibrosis severity in chronic hepatitis C patients.

KW - Acoustic Radiation Force Impulse Elastography (ARFI)

KW - Chronic hepatitis C

KW - Liver fibrosis

KW - Liver stiffness

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