Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation

A pilot study

Hirofumi Tomita, Ken Hoshino, Yasushi Fuchimoto, Hirotoshi Ebinuma, Kiyoshi Ohkuma, Yutaka Tanami, Wenlin Du, Yohei Masugi, Naoki Shimojima, Akihiro Fujino, Motohiro Kano, Takumi Fujimura, Hideo Ishihama, Takahiro Shimizu, Minoru Tanabe, Hidetsugu Saito, Michiie Sakamoto, Toshifumi Hibi, Yuukou Kitagawa, Tatsuo Kuroda

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Graft fibrosis is a common finding during protocol biopsy examinations after pediatric liver transplantation. We evaluated the clinical utility of liver stiffness measurements by acoustic radiation force impulse (ARFI) imaging, a novel ultrasound-based elastography method, for assessing graft fibrosis after pediatric living donor liver transplantation (LDLT). We performed 73 liver stiffness measurements by ARFI imaging in 65 pediatric LDLT recipients through the upper midline of the abdomen (midline value) and the right intercostal space (intercostal value) around the time of protocol biopsy examinations. Fifty-nine of these liver stiffness measurements could be compared with histopathological findings. Graft fibrosis was assessed according to the degrees of portal and pericellular fibrosis. Significant fibrosis, which was defined as F2 or worse portal fibrosis and/or moderate or worse pericellular fibrosis, was observed in 14 examinations, which had significantly higher midline (P = 0.005) and intercostal values (P < 0.001) than the others. Liver stiffness measurements by ARFI imaging significantly increased with increases in the portal and pericellular fibrosis grades. For the diagnosis of significant fibrosis, the areas under the receiver operating characteristic curve (AUROCs) were 0.760 (P = 0.005) and 0.849 (P < 0.001) for the midline and intercostal values, respectively. The optimal cutoff values were 1.30 and 1.39 m/second for midline and intercostal values, respectively. Slight but significant elevations were noted in the results of biochemical liver tests: serum levels of γ-glutamyltransferase showed the highest AUROC (0.809, P = 0.001) with an optimal cutoff value of 20 IU/L. In conclusion, liver stiffness measurements by ARFI imaging had good accuracy for diagnosing graft fibrosis after pediatric LDLT. The pericellular pattern of fibrosis was frequently observed after pediatric LDLT, and moderate pericellular fibrosis was detectable by ARFI imaging. Liver Transpl 19:1202-1213, 2013.

Original languageEnglish
Pages (from-to)1202-1213
Number of pages12
JournalLiver Transplantation
Volume19
Issue number11
DOIs
Publication statusPublished - 2013 Nov

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Elasticity Imaging Techniques
Living Donors
Liver Transplantation
Fibrosis
Pediatrics
Transplants
Liver
ROC Curve
Biopsy
Abdomen

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Hepatology
  • Medicine(all)

Cite this

Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation : A pilot study. / Tomita, Hirofumi; Hoshino, Ken; Fuchimoto, Yasushi; Ebinuma, Hirotoshi; Ohkuma, Kiyoshi; Tanami, Yutaka; Du, Wenlin; Masugi, Yohei; Shimojima, Naoki; Fujino, Akihiro; Kano, Motohiro; Fujimura, Takumi; Ishihama, Hideo; Shimizu, Takahiro; Tanabe, Minoru; Saito, Hidetsugu; Sakamoto, Michiie; Hibi, Toshifumi; Kitagawa, Yuukou; Kuroda, Tatsuo.

In: Liver Transplantation, Vol. 19, No. 11, 11.2013, p. 1202-1213.

Research output: Contribution to journalArticle

Tomita, H, Hoshino, K, Fuchimoto, Y, Ebinuma, H, Ohkuma, K, Tanami, Y, Du, W, Masugi, Y, Shimojima, N, Fujino, A, Kano, M, Fujimura, T, Ishihama, H, Shimizu, T, Tanabe, M, Saito, H, Sakamoto, M, Hibi, T, Kitagawa, Y & Kuroda, T 2013, 'Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation: A pilot study', Liver Transplantation, vol. 19, no. 11, pp. 1202-1213. https://doi.org/10.1002/lt.23708
Tomita, Hirofumi ; Hoshino, Ken ; Fuchimoto, Yasushi ; Ebinuma, Hirotoshi ; Ohkuma, Kiyoshi ; Tanami, Yutaka ; Du, Wenlin ; Masugi, Yohei ; Shimojima, Naoki ; Fujino, Akihiro ; Kano, Motohiro ; Fujimura, Takumi ; Ishihama, Hideo ; Shimizu, Takahiro ; Tanabe, Minoru ; Saito, Hidetsugu ; Sakamoto, Michiie ; Hibi, Toshifumi ; Kitagawa, Yuukou ; Kuroda, Tatsuo. / Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation : A pilot study. In: Liver Transplantation. 2013 ; Vol. 19, No. 11. pp. 1202-1213.
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AU - Ebinuma, Hirotoshi

AU - Ohkuma, Kiyoshi

AU - Tanami, Yutaka

AU - Du, Wenlin

AU - Masugi, Yohei

AU - Shimojima, Naoki

AU - Fujino, Akihiro

AU - Kano, Motohiro

AU - Fujimura, Takumi

AU - Ishihama, Hideo

AU - Shimizu, Takahiro

AU - Tanabe, Minoru

AU - Saito, Hidetsugu

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