Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features

Naoto Kuroda, Masato Tamura, Nobumasa Hamaguchi, Shuji Mikami, Chin Chen Pan, Matteo Brunelli, Guido Martignoni, Ondrej Hes, Michal Michal, Gang Hong Lee

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30 Citations (Scopus)

Abstract

Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume15
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

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Keywords

  • Acquired cystic disease
  • Renal cell carcinoma
  • Rhabdoid features
  • Sarcomatoid change

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kuroda, N., Tamura, M., Hamaguchi, N., Mikami, S., Pan, C. C., Brunelli, M., Martignoni, G., Hes, O., Michal, M., & Lee, G. H. (2011). Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features. Annals of Diagnostic Pathology, 15(6), 462-466. https://doi.org/10.1016/j.anndiagpath.2010.07.008