Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features

Naoto Kuroda, Masato Tamura, Nobumasa Hamaguchi, Shuji Mikami, Chin Chen Pan, Matteo Brunelli, Guido Martignoni, Ondrej Hes, Michal Michal, Gang Hong Lee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume15
Issue number6
DOIs
Publication statusPublished - 2011 Dec

Fingerprint

Cystic Kidney Diseases
Renal Cell Carcinoma
Kidney
Chromosomes, Human, Pair 14
Neoplasms
Chromosomes, Human, Pair 9
Kidney Neoplasms
Thoracic Wall
Vimentin
Keratins
Karyotype
Renal Dialysis

Keywords

  • Acquired cystic disease
  • Renal cell carcinoma
  • Rhabdoid features
  • Sarcomatoid change

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features. / Kuroda, Naoto; Tamura, Masato; Hamaguchi, Nobumasa; Mikami, Shuji; Pan, Chin Chen; Brunelli, Matteo; Martignoni, Guido; Hes, Ondrej; Michal, Michal; Lee, Gang Hong.

In: Annals of Diagnostic Pathology, Vol. 15, No. 6, 12.2011, p. 462-466.

Research output: Contribution to journalArticle

Kuroda, N, Tamura, M, Hamaguchi, N, Mikami, S, Pan, CC, Brunelli, M, Martignoni, G, Hes, O, Michal, M & Lee, GH 2011, 'Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features', Annals of Diagnostic Pathology, vol. 15, no. 6, pp. 462-466. https://doi.org/10.1016/j.anndiagpath.2010.07.008
Kuroda, Naoto ; Tamura, Masato ; Hamaguchi, Nobumasa ; Mikami, Shuji ; Pan, Chin Chen ; Brunelli, Matteo ; Martignoni, Guido ; Hes, Ondrej ; Michal, Michal ; Lee, Gang Hong. / Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features. In: Annals of Diagnostic Pathology. 2011 ; Vol. 15, No. 6. pp. 462-466.
@article{f41a4412c97d4606bbb531a18ae2539a,
title = "Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features",
abstract = "Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.",
keywords = "Acquired cystic disease, Renal cell carcinoma, Rhabdoid features, Sarcomatoid change",
author = "Naoto Kuroda and Masato Tamura and Nobumasa Hamaguchi and Shuji Mikami and Pan, {Chin Chen} and Matteo Brunelli and Guido Martignoni and Ondrej Hes and Michal Michal and Lee, {Gang Hong}",
year = "2011",
month = "12",
doi = "10.1016/j.anndiagpath.2010.07.008",
language = "English",
volume = "15",
pages = "462--466",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features

AU - Kuroda, Naoto

AU - Tamura, Masato

AU - Hamaguchi, Nobumasa

AU - Mikami, Shuji

AU - Pan, Chin Chen

AU - Brunelli, Matteo

AU - Martignoni, Guido

AU - Hes, Ondrej

AU - Michal, Michal

AU - Lee, Gang Hong

PY - 2011/12

Y1 - 2011/12

N2 - Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.

AB - Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.

KW - Acquired cystic disease

KW - Renal cell carcinoma

KW - Rhabdoid features

KW - Sarcomatoid change

UR - http://www.scopus.com/inward/record.url?scp=81155151396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81155151396&partnerID=8YFLogxK

U2 - 10.1016/j.anndiagpath.2010.07.008

DO - 10.1016/j.anndiagpath.2010.07.008

M3 - Article

VL - 15

SP - 462

EP - 466

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 6

ER -