Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions

Masahiro Kondo, Kunihiro Yamaoka, Yoshiya Tanaka

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of the limited regenerative ability of chondrocytes, defects in cartilage are irreversible and difficult to repair. Mesenchymal stem cells (MSCs) are expected to be a new tool for cartilage repair because they are present in the cartilage and are able to differentiate into multiple lineages of cells, including chondrocytes. Although clinical trials using MSCs for patients with cartilage defects have already begun, its efficacy and repair mechanisms remain unknown. A PubMed search conducted in October 2014 using the following medical subject headings (MeSH) terms: mesenchymal stromal cells, chondrogenesis, and cytokines resulted in 204 articles. The titles and abstracts were screened and nine articles relevant to "inflammatory" cytokines and "human" MSCs were identified. Herein, we review the cell biology and mechanisms of chondrocyte phenotype acquisition from human MSCs in an inflammatory milieu and discuss the clinical potential of MSCs for cartilage repair.

Original languageEnglish
Pages (from-to)21270-21285
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume15
Issue number11
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

cartilage
phenotype
stem cells
Cartilage
Chondrocytes
Stem cells
Mesenchymal Stromal Cells
Phenotype
Repair
Cartilage Diseases
Medical Subject Headings
Cytokines
Chondrogenesis
Cytology
arthritis
Defects
PubMed
defects
Osteoarthritis
apoptosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions. / Kondo, Masahiro; Yamaoka, Kunihiro; Tanaka, Yoshiya.

In: International Journal of Molecular Sciences, Vol. 15, No. 11, 2014, p. 21270-21285.

Research output: Contribution to journalReview article

Kondo, Masahiro ; Yamaoka, Kunihiro ; Tanaka, Yoshiya. / Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 11. pp. 21270-21285.
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