Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Tomonori Nakamura, Emi Okuyama, Atsushi Tsukada, Mikio Yamazaki, Motoyoshi Satake, Sansei Nishibe, Takeshi Deyama, Akira Moriya, Masao Maruno, Hiroaki Nishimura

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number3
Publication statusPublished - 1997 Mar
Externally publishedYes

Fingerprint

Lippia
Medicinal Plants
Analgesics
Oral Administration
Verbenaceae
Methamphetamine
Pentobarbital
Locomotion
Intravenous Injections
Acetic Acid
Intravenous Administration
Analgesia
Tail
Anesthesia
Pressure
Pain
acteoside

Keywords

  • acteoside
  • analgesia
  • Lippia triphylla
  • phenylethanoid glycoside
  • sedation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Nakamura, T., Okuyama, E., Tsukada, A., Yamazaki, M., Satake, M., Nishibe, S., ... Nishimura, H. (1997). Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant. Chemical and Pharmaceutical Bulletin, 45(3), 499-504.

Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant. / Nakamura, Tomonori; Okuyama, Emi; Tsukada, Atsushi; Yamazaki, Mikio; Satake, Motoyoshi; Nishibe, Sansei; Deyama, Takeshi; Moriya, Akira; Maruno, Masao; Nishimura, Hiroaki.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 3, 03.1997, p. 499-504.

Research output: Contribution to journalArticle

Nakamura, T, Okuyama, E, Tsukada, A, Yamazaki, M, Satake, M, Nishibe, S, Deyama, T, Moriya, A, Maruno, M & Nishimura, H 1997, 'Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant', Chemical and Pharmaceutical Bulletin, vol. 45, no. 3, pp. 499-504.
Nakamura, Tomonori ; Okuyama, Emi ; Tsukada, Atsushi ; Yamazaki, Mikio ; Satake, Motoyoshi ; Nishibe, Sansei ; Deyama, Takeshi ; Moriya, Akira ; Maruno, Masao ; Nishimura, Hiroaki. / Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant. In: Chemical and Pharmaceutical Bulletin. 1997 ; Vol. 45, No. 3. pp. 499-504.
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