Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant

Tomonori Nakamura, Emi Okuyama, Atsushi Tsukada, Mikio Yamazaki, Motoyoshi Satake, Sansei Nishibe, Takeshi Deyama, Akira Moriya, Masao Maruno, Hiroaki Nishimura

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66 Citations (Scopus)

Abstract

Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number3
Publication statusPublished - 1997 Mar
Externally publishedYes

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Keywords

  • acteoside
  • analgesia
  • Lippia triphylla
  • phenylethanoid glycoside
  • sedation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Nakamura, T., Okuyama, E., Tsukada, A., Yamazaki, M., Satake, M., Nishibe, S., Deyama, T., Moriya, A., Maruno, M., & Nishimura, H. (1997). Acteoside as the analgesic principle of Cedron (Lippia triphylla), a Peruvian medicinal plant. Chemical and Pharmaceutical Bulletin, 45(3), 499-504.