Action of nitrile hydratase from rhodococcus rhodochrous IFO 15564 on Derivatives of 2,5-Anhydro-d-allononitrile

Masahiro Yokoyama; Yuko Nakatsuka; Takeshi Sugai; Hiromichi Ohta

doi:10.1271/bbb.60.1540

Action of nitrile hydratase from rhodococcus rhodochrous IFO 15564 on Derivatives of 2,5-Anhydro-d-allononitrile

Masahiro Yokoyama, Yuko Nakatsuka, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The conversion of 2,5-anhydro-d-allononitrile derivatives by a nitrile hydratase from Rhodococcus rhodochrous IFO 15564 was studied. The activity of the enzyme was strongly effected by the steric bulkiness of the substituents at the 3-position of the substrates, and the corresponding amides were obtained in high yields from the nitriles with free hydroxyl groups at the 3- and 4-positions.

Original language	English
Pages (from-to)	1540-1542
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	60
Issue number	9
DOIs	https://doi.org/10.1271/bbb.60.1540
Publication status	Published - 1996 Jan

Keywords

2,5-anhydro-d-allonamide
2,5-anhydro-d-allononitrile
Hydantocidin
Nitrile hydratase
Rhodococcus rhodochrous IFO 15564

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Action of nitrile hydratase from rhodococcus rhodochrous IFO 15564 on Derivatives of 2,5-Anhydro-d-allononitrile",

abstract = "The conversion of 2,5-anhydro-d-allononitrile derivatives by a nitrile hydratase from Rhodococcus rhodochrous IFO 15564 was studied. The activity of the enzyme was strongly effected by the steric bulkiness of the substituents at the 3-position of the substrates, and the corresponding amides were obtained in high yields from the nitriles with free hydroxyl groups at the 3- and 4-positions.",

keywords = "2,5-anhydro-d-allonamide, 2,5-anhydro-d-allononitrile, Hydantocidin, Nitrile hydratase, Rhodococcus rhodochrous IFO 15564",

author = "Masahiro Yokoyama and Yuko Nakatsuka and Takeshi Sugai and Hiromichi Ohta",

year = "1996",

month = jan,

doi = "10.1271/bbb.60.1540",

language = "English",

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T1 - Action of nitrile hydratase from rhodococcus rhodochrous IFO 15564 on Derivatives of 2,5-Anhydro-d-allononitrile

AU - Yokoyama, Masahiro

AU - Nakatsuka, Yuko

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1996/1

Y1 - 1996/1

N2 - The conversion of 2,5-anhydro-d-allononitrile derivatives by a nitrile hydratase from Rhodococcus rhodochrous IFO 15564 was studied. The activity of the enzyme was strongly effected by the steric bulkiness of the substituents at the 3-position of the substrates, and the corresponding amides were obtained in high yields from the nitriles with free hydroxyl groups at the 3- and 4-positions.

AB - The conversion of 2,5-anhydro-d-allononitrile derivatives by a nitrile hydratase from Rhodococcus rhodochrous IFO 15564 was studied. The activity of the enzyme was strongly effected by the steric bulkiness of the substituents at the 3-position of the substrates, and the corresponding amides were obtained in high yields from the nitriles with free hydroxyl groups at the 3- and 4-positions.

KW - 2,5-anhydro-d-allonamide

KW - 2,5-anhydro-d-allononitrile

KW - Hydantocidin

KW - Nitrile hydratase

KW - Rhodococcus rhodochrous IFO 15564

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SN - 0916-8451

VL - 60

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EP - 1542

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 9

ER -

Action of nitrile hydratase from rhodococcus rhodochrous IFO 15564 on Derivatives of 2,5-Anhydro-d-allononitrile

Abstract

Keywords

ASJC Scopus subject areas

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