TY - JOUR
T1 - Activation-induced cytidine deaminase expression in CD4 + T cells is associated with a unique IL-10-producing subset that increases with age
AU - Qin, Hongyan
AU - Suzuki, Keiichiro
AU - Nakata, Mikiyo
AU - Chikuma, Shunsuke
AU - Izumi, Nakako
AU - Thi Huong, Le
AU - Maruya, Mikako
AU - Fagarasan, Sidonia
AU - Busslinger, Meinrad
AU - Honjo, Tasuku
AU - Nagaoka, Hitoshi
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12/28
Y1 - 2011/12/28
N2 - Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4 + T cells that had expressed Aicda (exAID cells) as well as B cells. ExAID cells increased with age, reaching up to 25% of the CD4 + and B220 + cell populations. ExAID B cells remained IgM +, suggesting that class-switched memory B cells do not accumulate in the spleen. In T cells, AID was expressed in a subset that produced IFN-γ and IL-10 but little IL-4 or IL-17, and showed no evidence of genetic mutation. Interestingly, the endogenous Aicda expression in T cells was enhanced in the absence of B cells, indicating that the process is independent from the germinal center reaction. These results suggest that in addition to its roles in B cells, AID may have previously unappreciated roles in T-cell function or tumorigenesis.
AB - Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4 + T cells that had expressed Aicda (exAID cells) as well as B cells. ExAID cells increased with age, reaching up to 25% of the CD4 + and B220 + cell populations. ExAID B cells remained IgM +, suggesting that class-switched memory B cells do not accumulate in the spleen. In T cells, AID was expressed in a subset that produced IFN-γ and IL-10 but little IL-4 or IL-17, and showed no evidence of genetic mutation. Interestingly, the endogenous Aicda expression in T cells was enhanced in the absence of B cells, indicating that the process is independent from the germinal center reaction. These results suggest that in addition to its roles in B cells, AID may have previously unappreciated roles in T-cell function or tumorigenesis.
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U2 - 10.1371/journal.pone.0029141
DO - 10.1371/journal.pone.0029141
M3 - Article
C2 - 22216188
AN - SCOPUS:84555203265
VL - 6
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
M1 - e29141
ER -