Activation of α7 nicotinic receptors suppresses sucrose addiction in mice

Namiko Kawamura, Ela Novianti, Nobuko Yamada-Goto, Riho Nakama, Akihiro Asakawa, Goro Katsuura, Akio Inui

Research output: Contribution to journalArticlepeer-review

Abstract

The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucrose preference and intake following sucrose withdrawal in mice were increased in comparison with the first set of trials. In the present study, α7, but not α4 and β2, nicotinic receptor subunit mRNA was decreased in the nucleus accumbens, but not in the hypothalamus, after sucrose withdrawal and subsequent sucrose intake. Administration of an agonist for α7, but not α4 and β2, nicotinic receptors suppressed the enhancement of sucrose preference and intake following sucrose withdrawal. These findings indicate that α7 nicotinic receptor activation suppresses sucrose addiction in a sucrose preference test in mice.

Original languageEnglish
Article number110439
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume113
DOIs
Publication statusPublished - 2022 Mar 8

Keywords

  • Food addiction
  • Mice
  • Nicotinic receptors
  • Sucrose preference
  • Sucrose withdrawal

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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