Abstract
Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the Pao2/Fio2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 μg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (ρ = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.
| Original language | English |
|---|---|
| Pages (from-to) | 1394-1399 |
| Number of pages | 6 |
| Journal | Anesthesia and Analgesia |
| Volume | 103 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2006 Dec |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass. / Kotani, Toru; Kotake, Yoshifumi; Morisaki, Hiroshi; Takeda, Junzo; Shimizu, Hideyuki; Ueda, Toshihiko; Ishizaka, Akitoshi.
In: Anesthesia and Analgesia, Vol. 103, No. 6, 12.2006, p. 1394-1399.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass
AU - Kotani, Toru
AU - Kotake, Yoshifumi
AU - Morisaki, Hiroshi
AU - Takeda, Junzo
AU - Shimizu, Hideyuki
AU - Ueda, Toshihiko
AU - Ishizaka, Akitoshi
PY - 2006/12
Y1 - 2006/12
N2 - Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the Pao2/Fio2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 μg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (ρ = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.
AB - Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the Pao2/Fio2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 μg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (ρ = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.
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U2 - 10.1213/01.ane.0000243391.05091.bb
DO - 10.1213/01.ane.0000243391.05091.bb
M3 - Article
VL - 103
SP - 1394
EP - 1399
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 6
ER -