Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass

Toru Kotani, Yoshifumi Kotake, Hiroshi Morisaki, Junzo Takeda, Hideyuki Shimizu, Toshihiko Ueda, Akitoshi Ishizaka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the Pao2/Fio2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 μg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (ρ = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.

Original languageEnglish
Pages (from-to)1394-1399
Number of pages6
JournalAnesthesia and analgesia
Volume103
Issue number6
DOIs
Publication statusPublished - 2006 Dec 1

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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