ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS.

Raphael M. Ottenbrite, Junzo Sunamoto, Toshinori Sato, Mikio Oka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Several polycarboxylic acid polymers have been found to exhibit a broad range of biological activities. One of the most interesting activities is the activation of macrophage cells to become cytotoxic to tumor cells. However, it is not known whether the macrophage are activated by internalizing the polymers or if it is a surface interaction. J. Sunamoto and co-workers have successfully established a methodology for evaluating drugs at the cell membrane level. In this study the propensity of several polyanionic polymers of known structure, molecular weight and biological activity to induce the lysis of liposomes was investigated.

Original languageEnglish
Title of host publicationAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
PublisherACS, Div of Polymer Chemistry
Pages212-213
Number of pages2
Volume26
Edition1
Publication statusPublished - 1985 Apr
Externally publishedYes

Fingerprint

Immunologic Factors
Polymers
Macrophages
Chemical activation
Bioactivity
Acids
Liposomes
Cell membranes
Tumors
Molecular weight
Cells
Pharmaceutical Preparations
Alveolar Macrophages
AS resin

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Ottenbrite, R. M., Sunamoto, J., Sato, T., & Oka, M. (1985). ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry (1 ed., Vol. 26, pp. 212-213). ACS, Div of Polymer Chemistry.

ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS. / Ottenbrite, Raphael M.; Sunamoto, Junzo; Sato, Toshinori; Oka, Mikio.

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 26 1. ed. ACS, Div of Polymer Chemistry, 1985. p. 212-213.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ottenbrite, RM, Sunamoto, J, Sato, T & Oka, M 1985, ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS. in American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1 edn, vol. 26, ACS, Div of Polymer Chemistry, pp. 212-213.
Ottenbrite RM, Sunamoto J, Sato T, Oka M. ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1 ed. Vol. 26. ACS, Div of Polymer Chemistry. 1985. p. 212-213
Ottenbrite, Raphael M. ; Sunamoto, Junzo ; Sato, Toshinori ; Oka, Mikio. / ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 26 1. ed. ACS, Div of Polymer Chemistry, 1985. pp. 212-213
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