ACTIVATION OF ALVEOLAR MACROPHAGES WITH POLYCARBOXYLIC ACID POLYMERS AS IMMUNOMODULATORS.

Raphael M. Ottenbrite, Junzo Sunamoto, Toshinori Sato, Mikio Oka

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Several polycarboxylic acid polymers have been found to exhibit a broad range of biological activities. One of the most interesting activities is the activation of macrophage cells to become cytotoxic to tumor cells. However, it is not known whether the macrophage are activated by internalizing the polymers or if it is a surface interaction. J. Sunamoto and co-workers have successfully established a methodology for evaluating drugs at the cell membrane level. In this study the propensity of several polyanionic polymers of known structure, molecular weight and biological activity to induce the lysis of liposomes was investigated.

Original languageEnglish
Pages (from-to)212-213
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume26
Issue number1
Publication statusPublished - 1985 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Polymers and Plastics

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