Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice

H. Nakashima, K. Omae, Toru Takebayashi, C. Ishizuka, H. Sakurai, K. Yamazaki, M. Nakaza, T. Shibata, M. Kudo, S. Koshi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron in diameter. The CL50 of DCS at 4-h exposure was 144 ppm (nominal concentration). In the acute inhalation study, ten mice in each group were exposed to 64 ppm (nominal concentration) DCS for 1, 2, 4 or 8 h. Body weight loss, wheezing and piloerection were observed in mice exposed for 2 h or more. Histopathologically, injury to the nasal mucosa and trachea were observed in all exposed mice. Mice exposed to 32 ppm (nominal concentration) DCS for 2 or 4 weeks also exhibited depression of body weight gain, wheezing and piloerection. Squamous metaplasia of the nasal mucosa and tracheal epithelium was observed in both 2- and 4-week exposure groups. Exposure to DCS was irritant or corrosive to the respiratory tract with both acute and subacute inhalation. Apart from silane (SiH4), toxic effects of DCS seem to be characterized by chloride compounds derived from DCS.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalArchives of Toxicology
Volume70
Issue number3-4
DOIs
Publication statusPublished - 1996 Jan

Fingerprint

Inbred ICR Mouse
Inhalation
Toxicity
Chlorides
Piloerection
Silanes
Caustics
Nasal Mucosa
Irritants
Poisons
Respiratory Sounds
Silicon
Air
Body Weight
Metaplasia
Trachea
Respiratory System
Weight Gain
Weight Loss
Epithelium

Keywords

  • Dichlorosilane
  • Inhalation toxicity
  • Mouse
  • Respiratory tract
  • Semiconductor
  • Squamous metaplasia

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Nakashima, H., Omae, K., Takebayashi, T., Ishizuka, C., Sakurai, H., Yamazaki, K., ... Koshi, S. (1996). Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice. Archives of Toxicology, 70(3-4), 218-223. https://doi.org/10.1007/s002040050263

Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice. / Nakashima, H.; Omae, K.; Takebayashi, Toru; Ishizuka, C.; Sakurai, H.; Yamazaki, K.; Nakaza, M.; Shibata, T.; Kudo, M.; Koshi, S.

In: Archives of Toxicology, Vol. 70, No. 3-4, 01.1996, p. 218-223.

Research output: Contribution to journalArticle

Nakashima, H, Omae, K, Takebayashi, T, Ishizuka, C, Sakurai, H, Yamazaki, K, Nakaza, M, Shibata, T, Kudo, M & Koshi, S 1996, 'Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice', Archives of Toxicology, vol. 70, no. 3-4, pp. 218-223. https://doi.org/10.1007/s002040050263
Nakashima, H. ; Omae, K. ; Takebayashi, Toru ; Ishizuka, C. ; Sakurai, H. ; Yamazaki, K. ; Nakaza, M. ; Shibata, T. ; Kudo, M. ; Koshi, S. / Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice. In: Archives of Toxicology. 1996 ; Vol. 70, No. 3-4. pp. 218-223.
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