Acute gastric mucosal lesions induced by vasomotor derangement —Participation of xanthine oxidase and neutrophil-mediated oxidative stress—

Masayuki Suzuki, Makoto Suematsu, Soichiro Miura, Masaya Oda, Masaharu Tsuchiya, Hiroshi Nagata, Tetsuo Morishita

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Gastric microcirculatory derangement following intermittent electrical stimuli on the main gastric artery produced many gastric ulcers in rat stomach. In this experimental model, the oxyradical generation from two different sources, xanthine-xanthine oxidase system and local neutrophils, were evaluated. Laser doppler flowmetry revealed that sharp fluctuation in mucosal blood flow took place during the repeated stimulation, while systemic blood pressure was unchanged. Thirty minutes after the irritation, the decrease in mucosal ATP contents and the increase of hypoxanthine contents were found. Xanthine oxidase activity in the gastric mucosa also elevated simultaneously. Moreover, both ChL activity of an individual neutrophil and mucosal myeloperoxidase activity were dramatically increased. Superoxide dismutase, chlorpromazine and allopurinol significantly inhibited the formation of gastric ulcers, and attenuated both oxyradical generation of neutrophils and xanthine-xanthine oxidase system. The present result suggests that microvascular derangement can cause the increase in oxidative stress mediated by neutrophils and xanthine oxidase system, which may participate in the formation of acute gastric lesions.

Original languageEnglish
Pages (from-to)835-842
Number of pages8
JournalNippon Shokakibyo Gakkai Zasshi
Volume85
Issue number4
DOIs
Publication statusPublished - 1988 Jan 1

ASJC Scopus subject areas

  • Gastroenterology

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