Acute hemodynamic and glycolytic metabolic changes of liposome embedded heme (L/H) in the hemorrhagic dog

Masazumi Watanabe, Koichi Kobayashi, Tsuneo Ishihara, Hiroyuki Nishide, Eisyun Tsuchida

Research output: Contribution to journalArticle

Abstract

The effects of intravenous transfusion of liposome-embedded heme (L/H) on acute hemodynamic and glycolytic metabolic changes were evaluated in hemorrhagic dogs. Under controlled ventilation, 30 ml/ kg of blood was drawn. Blood pressure, histamine release, PAP, PCWP, CVP and CO were measured. After 30 minutes, 30 ml/kg of L/H solution (group A) or normal saline solution (group B) was intravenously injected, and no transfusion was peformed in group C. The above parameters and serum lactate and pyruvate concentration were measured. The data obtained show that hemorrhagic hypotension and anaerobic glycolysis were reversed by L/H injection.

Original languageEnglish
Pages (from-to)502
Number of pages1
JournalBiomaterials, Artificial Cells, and Immobilization Biotechnology
Volume19
Issue number2
Publication statusPublished - 1991

Fingerprint

Liposomes
Hemodynamics
Heme
Dogs
Histamine Release
Blood pressure
Glycolysis
Carbon Monoxide
Pyruvic Acid
Sodium Chloride
Hypotension
Ventilation
Lactic Acid
Blood
Blood Pressure
Injections
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute hemodynamic and glycolytic metabolic changes of liposome embedded heme (L/H) in the hemorrhagic dog. / Watanabe, Masazumi; Kobayashi, Koichi; Ishihara, Tsuneo; Nishide, Hiroyuki; Tsuchida, Eisyun.

In: Biomaterials, Artificial Cells, and Immobilization Biotechnology, Vol. 19, No. 2, 1991, p. 502.

Research output: Contribution to journalArticle

Watanabe, Masazumi ; Kobayashi, Koichi ; Ishihara, Tsuneo ; Nishide, Hiroyuki ; Tsuchida, Eisyun. / Acute hemodynamic and glycolytic metabolic changes of liposome embedded heme (L/H) in the hemorrhagic dog. In: Biomaterials, Artificial Cells, and Immobilization Biotechnology. 1991 ; Vol. 19, No. 2. pp. 502.
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