Acute kidney injury due to renal sarcoidosis during etanercept therapy: A case report and literature review

Mitsuhiro Akiyama, Yuko Kaneko, Hironari Hanaoka, Masataka Kuwana, Tsutomu Takeuchi

Research output: Contribution to journalArticle

7 Citations (Scopus)


We herein report a case of renal sarcoidosis presenting as acute kidney injury (AKI) during treatment with etanercept for rheumatoid arthritis. Blood tests showed a high level of angiotensin-converting enzyme and a renal biopsy demonstrated non-caseating granulomatous tubulointerstitial nephritis. The administration of high-dose steroid therapy (1 mg/kg) and discontinuation of etanercept resulted in an improvement in the patient’s renal function. Although renal sarcoidosis induced by anti-tumor necrosis factor (TNF) therapy is an extremely rare manifestation, this case suggests that renal sarcoidosis should be considered in the differential diagnosis of AKI in patients receiving anti-TNF therapy, as providing an early diagnosis and treatment is important for preventing irreversible renal impairment.

Original languageEnglish
Pages (from-to)1131-1134
Number of pages4
JournalInternal Medicine
Issue number9
Publication statusPublished - 2015 Jan 1



  • Acute kidney injury
  • Anti-tumor necrosis factor
  • Renal sarcoidosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Internal Medicine

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