Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions

Hajime Okita, Akihiro Umezawa, Mariko Fukuma, Takashi Ando, Fumihiko Urano, Makoto Sano, Yuji Nakata, Taijiro Mori, Jun Ichi Hata

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Jumping translocations (JTs) are unbalanced chromosomal translocations in which an identical chromosomal region is translocated to the telomeric region of different chromosomes. JTs are rare in hematological malignancies where they are second translocations and may be an indicator of poor prognosis. We report a case of acute myeloid leukemia with t(16;21) and a JT in which the long arm of chromosome 1 distal to q21 is translocated to the terminal region of chromosome 10. The leukemic cells exhibit high expression of EAT/mcl1, an anti-apoptotic Bcl-2 related gene. Since EAT/mcl1 is mapped to 1q21 near the breakpoint in the JTs, high level expression of EAT/mcl1 may be associated with the poor prognosis of leukemia with JTs.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalLeukemia Research
Volume24
Issue number1
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Acute myeloid leukemia
  • Apoptosis
  • Bcl-2
  • EAT/mcl1
  • Jumping translocation
  • TLS/FUS-ERG

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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