@article{9c2202abec384845984bbc20052648fc,
title = "Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions",
abstract = "Jumping translocations (JTs) are unbalanced chromosomal translocations in which an identical chromosomal region is translocated to the telomeric region of different chromosomes. JTs are rare in hematological malignancies where they are second translocations and may be an indicator of poor prognosis. We report a case of acute myeloid leukemia with t(16;21) and a JT in which the long arm of chromosome 1 distal to q21 is translocated to the terminal region of chromosome 10. The leukemic cells exhibit high expression of EAT/mcl1, an anti-apoptotic Bcl-2 related gene. Since EAT/mcl1 is mapped to 1q21 near the breakpoint in the JTs, high level expression of EAT/mcl1 may be associated with the poor prognosis of leukemia with JTs.",
keywords = "Acute myeloid leukemia, Apoptosis, Bcl-2, EAT/mcl1, Jumping translocation, TLS/FUS-ERG",
author = "Hajime Okita and Akihiro Umezawa and Mariko Fukuma and Takashi Ando and Fumihiko Urano and Makoto Sano and Yuji Nakata and Taijiro Mori and Hata, {Jun Ichi}",
note = "Funding Information: The authors are grateful to J. Ozawa and M. Takahashi for their technical assistance, K. Takeichi for photographic assistance, and Drs T. Yamada, H. Kikuchi, A. Hashiguchi, A. Takata, A. Suzuki and T. Atsumi for discussion. This work was supported in part by a grant from the Ministry of Education, Science and Culture to JH and AU, by Keio University Special Grant-in-Aid for Innovative Collaborative Research Project to JH and AU, by a grant from the Keio Medical Association to HO, and by a National Grant-in-Aid for the Establishment of a High-Tech Research Center at Private Universities. H. Okita contributed to the concept, design, data analyses and drafted the paper. A. Umezawa contributed also to the concept, design, critical revision and provided funding for the project. M. Fukuma, T. Ando, F. Urano and M. Sano provided analysis and data interpretation. Y. Nakata and T. Mori provided study materials. J. Hata provided administrative and funding support and gave final approval for the paper.",
year = "2000",
month = jan,
doi = "10.1016/S0145-2126(99)00137-X",
language = "English",
volume = "24",
pages = "73--77",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "1",
}
