Acute myeloid leukemia presenting with obstructive jaundice and granulocytic sarcoma of the common bile duct

Yoshinori Mano, Kenji Yokoyama, Chien Kang Chen, Yuiko Tsukada, Yasuo Ikeda, Shinichiro Okamoto

Research output: Contribution to journalArticle

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Abstract

A 55-year-old man presented with jaundice and edema of the right leg. Tests of the peripheral blood and bone marrow showed leukocytopenia with 6% blasts and 38.3% of myeloperoxidase-positive blasts, respectively. Computed tomography (CT) scanning disclosed thickening of the common bile duct wall. Granulocytic sarcomas were also found at the left chest wall and the pelvic floor. Endoscopic retrograde cholangiopancreatography confirmed the narrowing of the common bile duct. Biopsy specimens of the common bile duct and pelvic masses revealed myeloblastic infiltration. After placement of a naso-biliary drainage tube, chemotherapy consisting of cytarabine (100 mg/m2/ day for 7 days) and idarubicin (12 mg/m2/ day for 3 days) was commenced. The dose of idarubicin was not modified. No serious complications, including delayed hematopoietic recovery, were observed after chemotherapy, and a complete remission was obtained 35 days later. Jaundice and liver dysfunction also gradually improved. The patient continues to receive consolidation therapy and remains in remission 8 months after the onset of his illness.

Original languageEnglish
Pages (from-to)1039-1043
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume45
Issue number9
Publication statusPublished - 2004

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Myeloid Sarcoma
Obstructive Jaundice
Common Bile Duct
Acute Myeloid Leukemia
Idarubicin
Jaundice
Drug Therapy
Pelvic Floor
Endoscopic Retrograde Cholangiopancreatography
Cytarabine
Leukopenia
Hematologic Tests
Thoracic Wall
Peroxidase
Liver Diseases
Drainage
Edema
Leg
Bone Marrow
Tomography

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Acute myeloid leukemia presenting with obstructive jaundice and granulocytic sarcoma of the common bile duct. / Mano, Yoshinori; Yokoyama, Kenji; Chen, Chien Kang; Tsukada, Yuiko; Ikeda, Yasuo; Okamoto, Shinichiro.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 45, No. 9, 2004, p. 1039-1043.

Research output: Contribution to journalArticle

Mano, Yoshinori ; Yokoyama, Kenji ; Chen, Chien Kang ; Tsukada, Yuiko ; Ikeda, Yasuo ; Okamoto, Shinichiro. / Acute myeloid leukemia presenting with obstructive jaundice and granulocytic sarcoma of the common bile duct. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2004 ; Vol. 45, No. 9. pp. 1039-1043.
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