Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome

Isao Shiraishi, Kunihiro Nishimura, Heima Sakaguchi, Tadaaki Abe, Masataka Kitano, Kenichi Kurosaki, Hitoshi Kato, Toshio Nakanishi, Hiroyuki Yamagishi, Koichi Sagawa, Yoshihiko Ikeda, Takayuki Morisaki, Takaya Hoashi, Koji Kagisaki, Hajime Ichikawa

Research output: Contribution to journalArticle

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Abstract

Background: Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition. Methods and Results-Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. The clinical manifestations, management strategies, and prognosis were investigated. Eighty-one (85%) patients were between 4 and 6 months (median, 5 months) of age. In 63 (66%) patients, rupture occurred during the spring or summer. The underlying conditions before rupture included Kawasaki disease (10 cases), maternally derived anti-SSA antibodies (2 cases), and infective endocarditis (1 case). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations of the mitral valves and chordae (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64%) and increased fibrous and myxoid tissue in 11 cases (39%), suggesting that nonbacterial infectious or autoimmune endocarditis and myxoid changes are involved in the pathogenesis. Eight patients (8.4%) died before (n=6) and shortly after (n=2) the operation, and significant neurological complications persisted in 10 cases (11%). Conclusions-Acute heart failure attributable to rupture of the mitral chordae tendineae in infants is a unique disease resulting from diverse causes. This condition should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.

Original languageEnglish
Pages (from-to)1053-1061
Number of pages9
JournalCirculation
Volume130
Issue number13
DOIs
Publication statusPublished - 2014

Fingerprint

Chordae Tendineae
Mitral Valve
Rupture
Japan
Endocarditis
Heart Failure
Mucocutaneous Lymph Node Syndrome
Cardiogenic Shock
Anti-Idiotypic Antibodies
Surveys and Questionnaires

Keywords

  • Heart failure
  • Mitral regurgitation
  • Pathology surgical
  • Pediatrics

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Shiraishi, I., Nishimura, K., Sakaguchi, H., Abe, T., Kitano, M., Kurosaki, K., ... Ichikawa, H. (2014). Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome. Circulation, 130(13), 1053-1061. https://doi.org/10.1161/CIRCULATIONAHA.114.008592

Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome. / Shiraishi, Isao; Nishimura, Kunihiro; Sakaguchi, Heima; Abe, Tadaaki; Kitano, Masataka; Kurosaki, Kenichi; Kato, Hitoshi; Nakanishi, Toshio; Yamagishi, Hiroyuki; Sagawa, Koichi; Ikeda, Yoshihiko; Morisaki, Takayuki; Hoashi, Takaya; Kagisaki, Koji; Ichikawa, Hajime.

In: Circulation, Vol. 130, No. 13, 2014, p. 1053-1061.

Research output: Contribution to journalArticle

Shiraishi, I, Nishimura, K, Sakaguchi, H, Abe, T, Kitano, M, Kurosaki, K, Kato, H, Nakanishi, T, Yamagishi, H, Sagawa, K, Ikeda, Y, Morisaki, T, Hoashi, T, Kagisaki, K & Ichikawa, H 2014, 'Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome', Circulation, vol. 130, no. 13, pp. 1053-1061. https://doi.org/10.1161/CIRCULATIONAHA.114.008592
Shiraishi, Isao ; Nishimura, Kunihiro ; Sakaguchi, Heima ; Abe, Tadaaki ; Kitano, Masataka ; Kurosaki, Kenichi ; Kato, Hitoshi ; Nakanishi, Toshio ; Yamagishi, Hiroyuki ; Sagawa, Koichi ; Ikeda, Yoshihiko ; Morisaki, Takayuki ; Hoashi, Takaya ; Kagisaki, Koji ; Ichikawa, Hajime. / Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome. In: Circulation. 2014 ; Vol. 130, No. 13. pp. 1053-1061.
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abstract = "Background: Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition. Methods and Results-Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. The clinical manifestations, management strategies, and prognosis were investigated. Eighty-one (85{\%}) patients were between 4 and 6 months (median, 5 months) of age. In 63 (66{\%}) patients, rupture occurred during the spring or summer. The underlying conditions before rupture included Kawasaki disease (10 cases), maternally derived anti-SSA antibodies (2 cases), and infective endocarditis (1 case). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations of the mitral valves and chordae (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64{\%}) and increased fibrous and myxoid tissue in 11 cases (39{\%}), suggesting that nonbacterial infectious or autoimmune endocarditis and myxoid changes are involved in the pathogenesis. Eight patients (8.4{\%}) died before (n=6) and shortly after (n=2) the operation, and significant neurological complications persisted in 10 cases (11{\%}). Conclusions-Acute heart failure attributable to rupture of the mitral chordae tendineae in infants is a unique disease resulting from diverse causes. This condition should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.",
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T1 - Acute rupture of chordae tendineae of the mitral valve in infants a nationwide survey in Japan exploring a new syndrome

AU - Shiraishi, Isao

AU - Nishimura, Kunihiro

AU - Sakaguchi, Heima

AU - Abe, Tadaaki

AU - Kitano, Masataka

AU - Kurosaki, Kenichi

AU - Kato, Hitoshi

AU - Nakanishi, Toshio

AU - Yamagishi, Hiroyuki

AU - Sagawa, Koichi

AU - Ikeda, Yoshihiko

AU - Morisaki, Takayuki

AU - Hoashi, Takaya

AU - Kagisaki, Koji

AU - Ichikawa, Hajime

PY - 2014

Y1 - 2014

N2 - Background: Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition. Methods and Results-Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. The clinical manifestations, management strategies, and prognosis were investigated. Eighty-one (85%) patients were between 4 and 6 months (median, 5 months) of age. In 63 (66%) patients, rupture occurred during the spring or summer. The underlying conditions before rupture included Kawasaki disease (10 cases), maternally derived anti-SSA antibodies (2 cases), and infective endocarditis (1 case). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations of the mitral valves and chordae (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64%) and increased fibrous and myxoid tissue in 11 cases (39%), suggesting that nonbacterial infectious or autoimmune endocarditis and myxoid changes are involved in the pathogenesis. Eight patients (8.4%) died before (n=6) and shortly after (n=2) the operation, and significant neurological complications persisted in 10 cases (11%). Conclusions-Acute heart failure attributable to rupture of the mitral chordae tendineae in infants is a unique disease resulting from diverse causes. This condition should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.

AB - Background: Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition. Methods and Results-Ninety-five children with rupture of mitral chordae tendineae were identified in nationwide surveys of Japan diagnosed from 1995 to 2013. The clinical manifestations, management strategies, and prognosis were investigated. Eighty-one (85%) patients were between 4 and 6 months (median, 5 months) of age. In 63 (66%) patients, rupture occurred during the spring or summer. The underlying conditions before rupture included Kawasaki disease (10 cases), maternally derived anti-SSA antibodies (2 cases), and infective endocarditis (1 case). Surgery was performed in 80 patients (94 operations), and the final operations included plasty of mitral chordae in 52 cases and mechanical valve replacement in 26 cases. The histopathologic examinations of the mitral valves and chordae (n=28) revealed inflammatory reactions with predominant mononuclear cell infiltration in 18 cases (64%) and increased fibrous and myxoid tissue in 11 cases (39%), suggesting that nonbacterial infectious or autoimmune endocarditis and myxoid changes are involved in the pathogenesis. Eight patients (8.4%) died before (n=6) and shortly after (n=2) the operation, and significant neurological complications persisted in 10 cases (11%). Conclusions-Acute heart failure attributable to rupture of the mitral chordae tendineae in infants is a unique disease resulting from diverse causes. This condition should be recognized as a significant cardiovascular disorder that may cause sudden onset of cardiogenic shock and death in infants.

KW - Heart failure

KW - Mitral regurgitation

KW - Pathology surgical

KW - Pediatrics

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