Adamantinoma of the distal femur diagnosed 5 years after initial surgery

A case report

Kai Cao, Michiro Susa, Itsuo Watanabe, Kazumasa Nishimoto, Keisuke Horiuchi, Aya Sasaki, Yuichiro Hayashi, Katsura Emoto, Kaori Kameyama, Masaya Nakamura, Morio Matsumoto, Hideo Morioka

Research output: Contribution to journalArticle

Abstract

Background: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery. Case presentation: A 74-year-old Asian woman first complained of right knee pain without any cause. Radiographs demonstrated a 4×4.5 cm osteolytic lesion in her medial femoral condyle. Magnetic resonance imaging revealed a lesion which showed low signal on both T1 and T2-weighted image, and enhanced signal with gadolinium contrast administration. She underwent a wide resection of the lesion and was reconstructed with a tumor endoprosthesis. On histological examination, the tumor showed clusters of spindle-shaped and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due to the unusual localization and her age. Moreover, it was difficult to exclude metastatic carcinoma. Five years later, she was diagnosed with an abnormal shadow occupying the upper lobe of her right lung in a routine physical examination. She subsequently underwent a resection of the lung mass which histologically showed proliferation of spindle-shaped and squamoid epithelial cells. The histological similarity of the lung tumor and the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with metastasis to the upper lobe of her right lung. Conclusion: In this case report, we report the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review of the literature.

Original languageEnglish
Article number185
JournalJournal of Medical Case Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2016 Jun 23

Fingerprint

Adamantinoma
Femur
Thigh
Lung
Bone and Bones
Neoplasms
Epithelial Cells
Gadolinium
Physical Examination
Knee
Magnetic Resonance Imaging
Neoplasm Metastasis
Carcinoma
Pain

Keywords

  • Adamantinoma
  • Distal femur
  • Medial femoral condyle
  • Metastatic adamantinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cao, K., Susa, M., Watanabe, I., Nishimoto, K., Horiuchi, K., Sasaki, A., ... Morioka, H. (2016). Adamantinoma of the distal femur diagnosed 5 years after initial surgery: A case report. Journal of Medical Case Reports, 10(1), [185]. https://doi.org/10.1186/s13256-016-0974-8

Adamantinoma of the distal femur diagnosed 5 years after initial surgery : A case report. / Cao, Kai; Susa, Michiro; Watanabe, Itsuo; Nishimoto, Kazumasa; Horiuchi, Keisuke; Sasaki, Aya; Hayashi, Yuichiro; Emoto, Katsura; Kameyama, Kaori; Nakamura, Masaya; Matsumoto, Morio; Morioka, Hideo.

In: Journal of Medical Case Reports, Vol. 10, No. 1, 185, 23.06.2016.

Research output: Contribution to journalArticle

Cao, Kai ; Susa, Michiro ; Watanabe, Itsuo ; Nishimoto, Kazumasa ; Horiuchi, Keisuke ; Sasaki, Aya ; Hayashi, Yuichiro ; Emoto, Katsura ; Kameyama, Kaori ; Nakamura, Masaya ; Matsumoto, Morio ; Morioka, Hideo. / Adamantinoma of the distal femur diagnosed 5 years after initial surgery : A case report. In: Journal of Medical Case Reports. 2016 ; Vol. 10, No. 1.
@article{ccb6f6443bf9460186bb75ff993963b6,
title = "Adamantinoma of the distal femur diagnosed 5 years after initial surgery: A case report",
abstract = "Background: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery. Case presentation: A 74-year-old Asian woman first complained of right knee pain without any cause. Radiographs demonstrated a 4×4.5 cm osteolytic lesion in her medial femoral condyle. Magnetic resonance imaging revealed a lesion which showed low signal on both T1 and T2-weighted image, and enhanced signal with gadolinium contrast administration. She underwent a wide resection of the lesion and was reconstructed with a tumor endoprosthesis. On histological examination, the tumor showed clusters of spindle-shaped and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due to the unusual localization and her age. Moreover, it was difficult to exclude metastatic carcinoma. Five years later, she was diagnosed with an abnormal shadow occupying the upper lobe of her right lung in a routine physical examination. She subsequently underwent a resection of the lung mass which histologically showed proliferation of spindle-shaped and squamoid epithelial cells. The histological similarity of the lung tumor and the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with metastasis to the upper lobe of her right lung. Conclusion: In this case report, we report the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review of the literature.",
keywords = "Adamantinoma, Distal femur, Medial femoral condyle, Metastatic adamantinoma",
author = "Kai Cao and Michiro Susa and Itsuo Watanabe and Kazumasa Nishimoto and Keisuke Horiuchi and Aya Sasaki and Yuichiro Hayashi and Katsura Emoto and Kaori Kameyama and Masaya Nakamura and Morio Matsumoto and Hideo Morioka",
year = "2016",
month = "6",
day = "23",
doi = "10.1186/s13256-016-0974-8",
language = "English",
volume = "10",
journal = "Journal of Medical Case Reports",
issn = "1752-1947",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Adamantinoma of the distal femur diagnosed 5 years after initial surgery

T2 - A case report

AU - Cao, Kai

AU - Susa, Michiro

AU - Watanabe, Itsuo

AU - Nishimoto, Kazumasa

AU - Horiuchi, Keisuke

AU - Sasaki, Aya

AU - Hayashi, Yuichiro

AU - Emoto, Katsura

AU - Kameyama, Kaori

AU - Nakamura, Masaya

AU - Matsumoto, Morio

AU - Morioka, Hideo

PY - 2016/6/23

Y1 - 2016/6/23

N2 - Background: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery. Case presentation: A 74-year-old Asian woman first complained of right knee pain without any cause. Radiographs demonstrated a 4×4.5 cm osteolytic lesion in her medial femoral condyle. Magnetic resonance imaging revealed a lesion which showed low signal on both T1 and T2-weighted image, and enhanced signal with gadolinium contrast administration. She underwent a wide resection of the lesion and was reconstructed with a tumor endoprosthesis. On histological examination, the tumor showed clusters of spindle-shaped and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due to the unusual localization and her age. Moreover, it was difficult to exclude metastatic carcinoma. Five years later, she was diagnosed with an abnormal shadow occupying the upper lobe of her right lung in a routine physical examination. She subsequently underwent a resection of the lung mass which histologically showed proliferation of spindle-shaped and squamoid epithelial cells. The histological similarity of the lung tumor and the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with metastasis to the upper lobe of her right lung. Conclusion: In this case report, we report the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review of the literature.

AB - Background: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery. Case presentation: A 74-year-old Asian woman first complained of right knee pain without any cause. Radiographs demonstrated a 4×4.5 cm osteolytic lesion in her medial femoral condyle. Magnetic resonance imaging revealed a lesion which showed low signal on both T1 and T2-weighted image, and enhanced signal with gadolinium contrast administration. She underwent a wide resection of the lesion and was reconstructed with a tumor endoprosthesis. On histological examination, the tumor showed clusters of spindle-shaped and squamoid epithelial cells among the fibrous stroma. Adamantinoma was considered, however, the diagnosis was inconclusive due to the unusual localization and her age. Moreover, it was difficult to exclude metastatic carcinoma. Five years later, she was diagnosed with an abnormal shadow occupying the upper lobe of her right lung in a routine physical examination. She subsequently underwent a resection of the lung mass which histologically showed proliferation of spindle-shaped and squamoid epithelial cells. The histological similarity of the lung tumor and the femoral tumor led to the diagnosis of adamantinoma arising in her right medial femoral condyle with metastasis to the upper lobe of her right lung. Conclusion: In this case report, we report the clinical, radiographic, and histological features of an adamantinoma arising in the distal femur with a review of the literature.

KW - Adamantinoma

KW - Distal femur

KW - Medial femoral condyle

KW - Metastatic adamantinoma

UR - http://www.scopus.com/inward/record.url?scp=84975789685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975789685&partnerID=8YFLogxK

U2 - 10.1186/s13256-016-0974-8

DO - 10.1186/s13256-016-0974-8

M3 - Article

VL - 10

JO - Journal of Medical Case Reports

JF - Journal of Medical Case Reports

SN - 1752-1947

IS - 1

M1 - 185

ER -