Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp

Yasufumi Seki, Atsuhiro Ichihara, Yuki Mizuguchi, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocininduced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.

Original languageEnglish
Pages (from-to)972-979
Number of pages8
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number3
DOIs
Publication statusPublished - 2010 Jun 1

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Diabetes
  • Handle region peptide
  • Hypertension
  • Proteinuria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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