Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp

Yasufumi Seki, Atsuhiro Ichihara, Yuki Mizuguchi, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocininduced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.

Original languageEnglish
Pages (from-to)972-979
Number of pages8
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number3
Publication statusPublished - 2010 Jun 1

Fingerprint

Renin
Peptides
Angiotensin II
Kidney
imidapril
Nutrition
Rats
Arterial Pressure
Salts
Diet
Weights and Measures

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Diabetes
  • Handle region peptide
  • Hypertension
  • Proteinuria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Seki, Y., Ichihara, A., Mizuguchi, Y., Sakoda, M., Kurauchi-Mito, A., Narita, T., ... Itoh, H. (2010). Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp. Frontiers in Bioscience - Elite, 2 E(3), 972-979.

Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp. / Seki, Yasufumi; Ichihara, Atsuhiro; Mizuguchi, Yuki; Sakoda, Mariyo; Kurauchi-Mito, Asako; Narita, Tatsuya; Kinouchi, Kenichiro; Bokuda, Kanako; Itoh, Hiroshi.

In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 3, 01.06.2010, p. 972-979.

Research output: Contribution to journalArticle

Seki, Y, Ichihara, A, Mizuguchi, Y, Sakoda, M, Kurauchi-Mito, A, Narita, T, Kinouchi, K, Bokuda, K & Itoh, H 2010, 'Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp', Frontiers in Bioscience - Elite, vol. 2 E, no. 3, pp. 972-979.
Seki Y, Ichihara A, Mizuguchi Y, Sakoda M, Kurauchi-Mito A, Narita T et al. Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp. Frontiers in Bioscience - Elite. 2010 Jun 1;2 E(3):972-979.
Seki, Yasufumi ; Ichihara, Atsuhiro ; Mizuguchi, Yuki ; Sakoda, Mariyo ; Kurauchi-Mito, Asako ; Narita, Tatsuya ; Kinouchi, Kenichiro ; Bokuda, Kanako ; Itoh, Hiroshi. / Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp. In: Frontiers in Bioscience - Elite. 2010 ; Vol. 2 E, No. 3. pp. 972-979.
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