Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery

Yoshifumi Kotake, Midori Matsumoto, Kimiaki Ai, Hiroshi Morisaki, Junzo Takeda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Study Objective: To examine the effects of additional droperidol or butorphanol to epidural fentanyl infusion on postsurgical analgesia.Design: Prospective, randomized, single blinded clinical study.Setting: University-affiliated medical center.Patients: 60 ASA physical status I and II patients undergoing anorectal surgery by one surgeon.Interventions: Patients were randomly allocated to the following groups according to the medication that was continuously administered into the epidural space: 1) Group C (n = 20) received 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; 2) Group D (n = 20) received 2.5 mg droperidol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; and 3) Group B (n = 20) received 2 mg butorphanol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine over 24 hours postoperatively.Measurements and Main Result: Postsurgical analgesia and the incidence of fentanyl-related complications, such as nausea/vomiting, somnolence, pruritus, and respiratory depression, were assessed for 24 hours postoperatively. At 16 and 24 hours after surgery, 75% of patients in Group D reported no pain versus 35% in Group C (p < 0.05). In addition, the overall visual analogue scale examined at 24 hours was significantly lower in Group D than that in Group C (22 ± 17 mm vs. 44 ± 22 mm, respectively; p < 0.05). Simultaneously, the incidence of postoperative nausea/vomiting was lower in Group D compared with Group C (20% vs. 60%; p < 0.05). On the other hand, butorphanol did not modify the analgesic effects or complications of epidural fentanyl infusion.Conclusion: In this study population, additional droperidol, not butorphanol, improved postsurgical analgesia accompanied by less incidence of nausea/vomiting during epidural fentanyl administration. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Clinical Anesthesia
Volume12
Issue number1
DOIs
Publication statusPublished - 2000 Feb

Fingerprint

Butorphanol
Droperidol
Epidural Analgesia
Fentanyl
Bupivacaine
Analgesia
Nausea
Vomiting
Incidence
Epidural Space
Postoperative Nausea and Vomiting
Pruritus
Visual Analog Scale
Respiratory Insufficiency
Analgesics
Pain

Keywords

  • Analgesia
  • Butorphanol
  • Droperidol
  • Epidural
  • Fentanyl
  • Opioids
  • Postoperative

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery. / Kotake, Yoshifumi; Matsumoto, Midori; Ai, Kimiaki; Morisaki, Hiroshi; Takeda, Junzo.

In: Journal of Clinical Anesthesia, Vol. 12, No. 1, 02.2000, p. 9-13.

Research output: Contribution to journalArticle

Kotake, Yoshifumi ; Matsumoto, Midori ; Ai, Kimiaki ; Morisaki, Hiroshi ; Takeda, Junzo. / Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery. In: Journal of Clinical Anesthesia. 2000 ; Vol. 12, No. 1. pp. 9-13.
@article{49feb8bfd6ca4f8bb89b0f94504318a9,
title = "Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery",
abstract = "Study Objective: To examine the effects of additional droperidol or butorphanol to epidural fentanyl infusion on postsurgical analgesia.Design: Prospective, randomized, single blinded clinical study.Setting: University-affiliated medical center.Patients: 60 ASA physical status I and II patients undergoing anorectal surgery by one surgeon.Interventions: Patients were randomly allocated to the following groups according to the medication that was continuously administered into the epidural space: 1) Group C (n = 20) received 0.4 mg fentanyl in 40 ml of 0.125{\%} bupivacaine; 2) Group D (n = 20) received 2.5 mg droperidol and 0.4 mg fentanyl in 40 ml of 0.125{\%} bupivacaine; and 3) Group B (n = 20) received 2 mg butorphanol and 0.4 mg fentanyl in 40 ml of 0.125{\%} bupivacaine over 24 hours postoperatively.Measurements and Main Result: Postsurgical analgesia and the incidence of fentanyl-related complications, such as nausea/vomiting, somnolence, pruritus, and respiratory depression, were assessed for 24 hours postoperatively. At 16 and 24 hours after surgery, 75{\%} of patients in Group D reported no pain versus 35{\%} in Group C (p < 0.05). In addition, the overall visual analogue scale examined at 24 hours was significantly lower in Group D than that in Group C (22 ± 17 mm vs. 44 ± 22 mm, respectively; p < 0.05). Simultaneously, the incidence of postoperative nausea/vomiting was lower in Group D compared with Group C (20{\%} vs. 60{\%}; p < 0.05). On the other hand, butorphanol did not modify the analgesic effects or complications of epidural fentanyl infusion.Conclusion: In this study population, additional droperidol, not butorphanol, improved postsurgical analgesia accompanied by less incidence of nausea/vomiting during epidural fentanyl administration. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Analgesia, Butorphanol, Droperidol, Epidural, Fentanyl, Opioids, Postoperative",
author = "Yoshifumi Kotake and Midori Matsumoto and Kimiaki Ai and Hiroshi Morisaki and Junzo Takeda",
year = "2000",
month = "2",
doi = "10.1016/S0952-8180(99)00113-0",
language = "English",
volume = "12",
pages = "9--13",
journal = "Journal of Clinical Anesthesia",
issn = "0952-8180",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery

AU - Kotake, Yoshifumi

AU - Matsumoto, Midori

AU - Ai, Kimiaki

AU - Morisaki, Hiroshi

AU - Takeda, Junzo

PY - 2000/2

Y1 - 2000/2

N2 - Study Objective: To examine the effects of additional droperidol or butorphanol to epidural fentanyl infusion on postsurgical analgesia.Design: Prospective, randomized, single blinded clinical study.Setting: University-affiliated medical center.Patients: 60 ASA physical status I and II patients undergoing anorectal surgery by one surgeon.Interventions: Patients were randomly allocated to the following groups according to the medication that was continuously administered into the epidural space: 1) Group C (n = 20) received 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; 2) Group D (n = 20) received 2.5 mg droperidol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; and 3) Group B (n = 20) received 2 mg butorphanol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine over 24 hours postoperatively.Measurements and Main Result: Postsurgical analgesia and the incidence of fentanyl-related complications, such as nausea/vomiting, somnolence, pruritus, and respiratory depression, were assessed for 24 hours postoperatively. At 16 and 24 hours after surgery, 75% of patients in Group D reported no pain versus 35% in Group C (p < 0.05). In addition, the overall visual analogue scale examined at 24 hours was significantly lower in Group D than that in Group C (22 ± 17 mm vs. 44 ± 22 mm, respectively; p < 0.05). Simultaneously, the incidence of postoperative nausea/vomiting was lower in Group D compared with Group C (20% vs. 60%; p < 0.05). On the other hand, butorphanol did not modify the analgesic effects or complications of epidural fentanyl infusion.Conclusion: In this study population, additional droperidol, not butorphanol, improved postsurgical analgesia accompanied by less incidence of nausea/vomiting during epidural fentanyl administration. Copyright (C) 2000 Elsevier Science Inc.

AB - Study Objective: To examine the effects of additional droperidol or butorphanol to epidural fentanyl infusion on postsurgical analgesia.Design: Prospective, randomized, single blinded clinical study.Setting: University-affiliated medical center.Patients: 60 ASA physical status I and II patients undergoing anorectal surgery by one surgeon.Interventions: Patients were randomly allocated to the following groups according to the medication that was continuously administered into the epidural space: 1) Group C (n = 20) received 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; 2) Group D (n = 20) received 2.5 mg droperidol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine; and 3) Group B (n = 20) received 2 mg butorphanol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine over 24 hours postoperatively.Measurements and Main Result: Postsurgical analgesia and the incidence of fentanyl-related complications, such as nausea/vomiting, somnolence, pruritus, and respiratory depression, were assessed for 24 hours postoperatively. At 16 and 24 hours after surgery, 75% of patients in Group D reported no pain versus 35% in Group C (p < 0.05). In addition, the overall visual analogue scale examined at 24 hours was significantly lower in Group D than that in Group C (22 ± 17 mm vs. 44 ± 22 mm, respectively; p < 0.05). Simultaneously, the incidence of postoperative nausea/vomiting was lower in Group D compared with Group C (20% vs. 60%; p < 0.05). On the other hand, butorphanol did not modify the analgesic effects or complications of epidural fentanyl infusion.Conclusion: In this study population, additional droperidol, not butorphanol, improved postsurgical analgesia accompanied by less incidence of nausea/vomiting during epidural fentanyl administration. Copyright (C) 2000 Elsevier Science Inc.

KW - Analgesia

KW - Butorphanol

KW - Droperidol

KW - Epidural

KW - Fentanyl

KW - Opioids

KW - Postoperative

UR - http://www.scopus.com/inward/record.url?scp=0034072552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034072552&partnerID=8YFLogxK

U2 - 10.1016/S0952-8180(99)00113-0

DO - 10.1016/S0952-8180(99)00113-0

M3 - Article

C2 - 10773501

AN - SCOPUS:0034072552

VL - 12

SP - 9

EP - 13

JO - Journal of Clinical Anesthesia

JF - Journal of Clinical Anesthesia

SN - 0952-8180

IS - 1

ER -