Adenovirus-mediated gene therapy of liver diseases

Yaron Ilan, Hidetsugu Saito, Narsing R. Thummala, Namita Roy Chowdhury

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Recombinant adenoviruses can infect nondividing cells with high efficiency and are rapidly concentrated in the liver after systemic administration, making them attractive for use in liver-directed gene therapy. However, there are two hurdles to clinical application of these vectors. First, adenoviruses are episomal and have limited life spans within the cell. Second, host antiviral immune responses reduce the duration of vector persistence and preclude long-term transgene expression by repeated injection of the vector. Several strategies have been designed for abrogation of the specific antiadenoviral immune responses by modification of the host immune system or alteration of the vector. These strategies and the use of adenoviral vectors for the treatment of hereditary, infectious, and malignant diseases of the liver are discussed in this review.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalSeminars in Liver Disease
Volume19
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Adenoviral vectors
  • Gene therapy
  • Hepatic malignancies
  • Hereditary diseases
  • Infectious diseases

ASJC Scopus subject areas

  • Hepatology

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  • Cite this

    Ilan, Y., Saito, H., Thummala, N. R., & Roy Chowdhury, N. (1999). Adenovirus-mediated gene therapy of liver diseases. Seminars in Liver Disease, 19(1), 49-59. https://doi.org/10.1055/s-2007-1007097