Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

Aimin Tang, Masayuki Amagai, Lawrence G. Granger, John R. Stanley, Mark C. Uddy

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Abstract

Langerhans cells (LC) are the principal accessory cells present in epidermis Because LC have limited capacity for self-renewal epidermis is continually repopulated by as-yet uncharacterized bone marrow-derived LC progenitors In addition, although LC persist in epidermis for extended periods, LC are induced to migrate from skin to regional lymph nodes after antigen exposure To begin to elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte (KC) interactions. Here we report that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin. Cultured LC (which may bear a phenotypic and functional relationship to LC that have migrated to lymph nodes express lower levels of E-cadherin and exhibit.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalNature
Volume361
Issue number6407
DOIs
Publication statusPublished - 1993 Jan 1
Externally publishedYes

ASJC Scopus subject areas

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    Tang, A., Amagai, M., Granger, L. G., Stanley, J. R., & Uddy, M. C. (1993). Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature, 361(6407), 82-85. https://doi.org/10.1038/361082a0