Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

Aimin Tang, Masayuki Amagai, Lawrence G. Granger, John R. Stanley, Mark C. Udey

Research output: Contribution to journalArticle

386 Citations (Scopus)

Abstract

LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet uncharacterized bone marrow-derived LC progenitors3,4. In addition, although LC persist in epidermis for extended periods, LC are induced to migrate from skin to regional lymph nodes after antigen exposure5. To begin to elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte (KC) interactions. Here we report that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin. Cultured LC (which may bear a phenotypic and functional relationship to LC that have migrated to lymph nodes6,7) express lower levels of E-cadherin and exhibit decreased affinity for KC. These results suggest that expression of E-cadherin by LC promotes persistence of these cells in epidermis, and that cadherins may play important and unanticipated roles in interactions between leukocytes and epithelia.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalNature
Volume361
Issue number6407
Publication statusPublished - 1993 Jan 7
Externally publishedYes

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Langerhans Cells
Cadherins
Keratinocytes
Epidermis
Lymph
Cell Communication
Cultured Cells
Leukocytes
Epithelium
Lymph Nodes
Bone Marrow

ASJC Scopus subject areas

  • General

Cite this

Tang, A., Amagai, M., Granger, L. G., Stanley, J. R., & Udey, M. C. (1993). Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature, 361(6407), 82-85.

Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. / Tang, Aimin; Amagai, Masayuki; Granger, Lawrence G.; Stanley, John R.; Udey, Mark C.

In: Nature, Vol. 361, No. 6407, 07.01.1993, p. 82-85.

Research output: Contribution to journalArticle

Tang, A, Amagai, M, Granger, LG, Stanley, JR & Udey, MC 1993, 'Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin', Nature, vol. 361, no. 6407, pp. 82-85.
Tang A, Amagai M, Granger LG, Stanley JR, Udey MC. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature. 1993 Jan 7;361(6407):82-85.
Tang, Aimin ; Amagai, Masayuki ; Granger, Lawrence G. ; Stanley, John R. ; Udey, Mark C. / Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. In: Nature. 1993 ; Vol. 361, No. 6407. pp. 82-85.
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