Adipokines and aging: Findings from centenarians and the very old

Yasumichi Arai, Kei Kamide, Nobuyoshi Hirose

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Adipose tissue, which was once considered as a simple energy storage depot, is now recognized as an active endocrine organ that regulates the whole-body energy homeostasis by secreting hundreds of bioactive substances termed adipokines. Dysregulation of adipokines is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Adipokine dysregulation and insulin resistance are also associated with energy-deprivation conditions, such as frailty in old age. Previous studies have demonstrated that preserved insulin sensitivity and low prevalence of diabetes are the metabolic peculiarities of centenarians, suggesting the possible role of adipokine homeostasis in healthy longevity. Among the numerous adipokines, adiponectin is regarded as unique and salutary, showing negative correlations with several age- and obesity-related metabolic disturbances and a positive correlation with longevity and insulin sensitivity among centenarians. However, large-scale epidemiological studies have implied the opposite aspect of this adipokine as a prognostic factor for all-cause and cardiovascular mortality in patients with heart failure or kidney disease. In this review, the clinical significance of adiponectin was comparatively addressed in centenarians and the very old, in terms of frailty, cardiovascular risk, and mortality.

Original languageEnglish
Article number142
JournalFrontiers in Endocrinology
Volume10
Issue numberMAR
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Adipokines
Insulin Resistance
Adiponectin
Homeostasis
Obesity
Mortality
Kidney Diseases
Adipose Tissue
Epidemiologic Studies
Heart Diseases
Heart Failure

Keywords

  • adipokines
  • adiponectin
  • centenarian
  • frailty
  • longevity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Adipokines and aging : Findings from centenarians and the very old. / Arai, Yasumichi; Kamide, Kei; Hirose, Nobuyoshi.

In: Frontiers in Endocrinology, Vol. 10, No. MAR, 142, 01.01.2019.

Research output: Contribution to journalReview article

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