Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age

Yasumichi Arai, Michiyo Takayama, Yasuyuki Gondo, Hiroki Inagaki, Ken Yamamura, Susumu Nakazawa, Toshio Kojima, Yoshinori Ebihara, Kenichirou Shimizu, Yukie Masui, Koji Kitagawa, Toru Takebayashi, Nobuyoshi Hirose

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background. Observational studies have demonstrated similarities between the underpinning of frailty and biological features of centenarians, suggesting that adaptability to age-related multiple physiological decline may be a core component of successful aging. The aim of this study is to determine whether hormonal pathways potentially involved in energy homeostasis contribute to survival beyond 100 years of age. Methods. We assessed a total of 252 centenarians (mean [standard deviation (SD)] age, 101.5 (1.8) years, range 100-108 years) using a complete set of biomarkers of adipose endocrine function and the insulin-like growth factor-1 (IGF-1) axis. Conventional risk factors at baseline were also assessed. The participants were followed up for all-cause mortality every 12 months by telephone contact. Results. During 2253 days of follow-up, 208 centenarians (82.5%) died. The lowest tertile of leptin and the highest tertile of tumor necrosis factor-α were associated with higher mortality risk among centenarians after adjusting for age (per 6-month increase), sex, education, smoking, activities of daily living (ADL), cognitive function, and comorbidities (hazard ratio [HR] 1.6; 95% confidence interval [CI], 1.14-2.35; and HR 1.45; 95% CI, 1.00-2.08, respectively). The lowest tertiles of both IGF-1 and IGF binding protein 3 (IGFBP3) were also associated with increased mortality. The adipose risk score, indicating cumulative effects of adipokine dysregulation, was strongly associated with increased mortality risk; ADL; cognitive function; and levels of albumin, cholinesterase, high-density lipoprotein-cholesterol, C-reactive protein, interleukin 6, and IGF-1 at baseline. Conclusions. The results suggested that preservation of adipose endocrine function and the IGF-1 axis may be potentially important for maintaining health and function and promoting survival at an extremely old age.

Original languageEnglish
Pages (from-to)1209-1218
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume63
Issue number11
Publication statusPublished - 2008 Nov

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Somatomedins
Insulin-Like Growth Factor Binding Protein 3
Mortality
Activities of Daily Living
Cognition
Confidence Intervals
Adipokines
Sex Education
Cholinesterases
Leptin
Telephone
C-Reactive Protein
HDL Cholesterol
Observational Studies
Comorbidity
Albumins
Interleukin-6
Homeostasis
Tumor Necrosis Factor-alpha
Biomarkers

Keywords

  • Adiponectin
  • Centenarians
  • Frailty
  • Insulin-like growth factor 1
  • Leptin
  • Metabolic network
  • Mortality
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. / Arai, Yasumichi; Takayama, Michiyo; Gondo, Yasuyuki; Inagaki, Hiroki; Yamamura, Ken; Nakazawa, Susumu; Kojima, Toshio; Ebihara, Yoshinori; Shimizu, Kenichirou; Masui, Yukie; Kitagawa, Koji; Takebayashi, Toru; Hirose, Nobuyoshi.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 63, No. 11, 11.2008, p. 1209-1218.

Research output: Contribution to journalArticle

Arai, Y, Takayama, M, Gondo, Y, Inagaki, H, Yamamura, K, Nakazawa, S, Kojima, T, Ebihara, Y, Shimizu, K, Masui, Y, Kitagawa, K, Takebayashi, T & Hirose, N 2008, 'Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 63, no. 11, pp. 1209-1218.
Arai, Yasumichi ; Takayama, Michiyo ; Gondo, Yasuyuki ; Inagaki, Hiroki ; Yamamura, Ken ; Nakazawa, Susumu ; Kojima, Toshio ; Ebihara, Yoshinori ; Shimizu, Kenichirou ; Masui, Yukie ; Kitagawa, Koji ; Takebayashi, Toru ; Hirose, Nobuyoshi. / Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2008 ; Vol. 63, No. 11. pp. 1209-1218.
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AU - Inagaki, Hiroki

AU - Yamamura, Ken

AU - Nakazawa, Susumu

AU - Kojima, Toshio

AU - Ebihara, Yoshinori

AU - Shimizu, Kenichirou

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