A diversity scheme with Fractional Sampling (FS) in OFDM receivers has been investigated recently. In the previous literature it has been shown that performance improvement with path diversity through FS depends on the bandwidth of the total channel response including transmit and receive baseband filters. However, if the signal on the adjacent channel exists, that signal causes interference to the desired signal with FS. In this paper, an adjacent channel interference cancellation scheme has been proposed for the FS OFDM receiver. The proposed scheme demodulates the signal on the adjacent channel and regenerates it to be subtracted from the received signal. Numerical results through computer simulation show that the proposed scheme achieves BER improvement under low signal-to-interference-ratio (SIR) conditions.