Adjuvant chemotherapy for breast cancer--a current controversy

Hiromitsu Jinno, Tadashi Ikeda, Kouichi Kubouchi, Kiyoshi Fujiwara, Masaki Kitajima

Research output: Contribution to journalReview article


EBCTCG meta-analysis revealed a significant reduction in mortality in patients receiving chemotherapy irrespective of nodal status and ER status. Compared with CMF, 5-year RFS and OS favored the anthracycline-containing regimens, 57% vs 54% (p = 0.006) and 72% vs 69% (p = 0.02), respectively. No survival benefit was obtained for CMF durations greater than 6 months. Delaying radiation therapy for several months after breast-conserving surgery until the completion of adjuvant chemotherapy appears safe and may be preferable for patients at high risk of distant metastasis. No difference in disease-free survival for the 3 dose levels of doxorubicin (60, 75, and 90 mg/m2) was found. Higher doses (100 mg/m2) of epirubicin led to a high survival rate in women with poor-prognosis disease. Dose-dense therapy seems promising but still needs further investigation. Incorporation of taxanes into adjuvant chemotherapy for early breast cancer is also controversial.

Original languageEnglish
Pages (from-to)176-180
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number2
Publication statusPublished - 2004 Feb

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Jinno, H., Ikeda, T., Kubouchi, K., Fujiwara, K., & Kitajima, M. (2004). Adjuvant chemotherapy for breast cancer--a current controversy. Gan to kagaku ryoho. Cancer & chemotherapy, 31(2), 176-180.