Administration of corticosteroids, ascorbic acid, and thiamine improves oxygenation after thoracoscopic esophagectomy

Tadashi Matsuoka, Hiroharu Shinozaki, Soji Ozawa, Yoshimitsu Izawa, Kazuo Koyanagi, Alan Kawarai Lefor, Kenji Kobayashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Purpose: The activity of corticosteroids, ascorbic acid, and thiamine against oxidative and inflammatory responses was evaluated in patients undergoing esophagectomy. This study was undertaken to investigate the effect of this combined therapy on lung dysfunction following esophagectomy. Methods: In this retrospective before–after study, we compared the clinical course of con-secutive patients undergoing thoracoscopic esophagectomy treated with the combination of corticosteroids, ascorbic acid, and thiamine between June and December 2018 with a control group treated with corticosteroids alone between January 2016 and May 2018. Outcomes included oxygenation (arterial partial pressure of oxygen (PaO2)/fractional concentration of inspired oxygen (FiO2) ratios), duration of mechanical ventilation and intensive care unit (ICU) length of stay. Results: In all, 17 patients were included in this study (6 in the combination therapy group and 11 patients in the control group). Mean PaO2/FiO2 ratios in the combined therapy group were significantly higher than in the control group at all points during the observation period (p <0.001). In the combined therapy group, the duration of mechanical ventilation and ICU stay were significantly shorter (p <0.001, p = 0.009). Conclusions: This study suggests that combined therapy including corticosteroids, ascorbic acid, and thiamine may be effective in improving oxygenation after esophagectomy. Additional studies are required to confirm these preliminary findings.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalAnnals of Thoracic and Cardiovascular Surgery
Volume26
Issue number3
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Ascorbic acid
  • Corticosteroids
  • Esophagectomy
  • Lung injury

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Gastroenterology

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