Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes

Yudai Kitamura, Hiroyuki Sasamura, Tatsuya Maruyama, Hideaki Nakaya, Tetsuro Amemiya, Matsuhiko Hayashi, Takao Saruta

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cushing's and Conn's syndromes are well recognised endocrine diseases, but the pathobiology of the tumors causing these disorders is unclear. In this study we examined AT1 and AT2 gene expression in adrenal adenomas of Cushing's and Conn's syndromes. AT1 and AT2 receptor mRNA, as well as alternatively spliced AT1 transcripts, were detected by RT-PCR using adjacent adrenal cortex tissue as controls. Whereas no consistent differences in AT1 mRNA were seen compared to control adrenal cortex, AT2 mRNA levels were significantly decreased in the adenomas of Cushing's and Conn's syndromes. No changes in alternative splicing of AT1 mRNA were observed in the adrenal tumors. The fact that no consistent changes were seen in AT1 mRNA or its splicing, whereas AT2 mRNA were reduced in both forms of hormone producing adrenal tumor suggests that the AT2 receptor, rather than the AT1 subtype, may be correlated with adrenal tumorigenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume144
Issue number1-2
DOIs
Publication statusPublished - 1998 Sep 25

Keywords

  • Adenoma
  • Adrenal
  • Angiotensin II
  • Conn
  • Cushing
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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    Kitamura, Y., Sasamura, H., Maruyama, T., Nakaya, H., Amemiya, T., Hayashi, M., & Saruta, T. (1998). Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes. Molecular and Cellular Endocrinology, 144(1-2), 37-45. https://doi.org/10.1016/S0303-7207(98)00159-2