Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

Hiromu Monai, Xiaowen Wang, Kazuko Yahagi, Nanhong Lou, Humberto Mestre, Qiwu Xu, Yoichiro Abe, Masato Yasui, Youichi Iwai, Maiken Nedergaard, Hajime Hirase

Research output: Contribution to journal › Article

Abstract

Spontaneous waves of cortical spreading depolarization (CSD) are induced in the setting of acute focal ischemia. CSD is linked to a sharp increase of extracellular K+ that induces a long-lasting suppression of neural activity. Furthermore, CSD induces secondary irreversible damage in the ischemic brain, suggesting that K+ homeostasis might constitute a therapeutic strategy in ischemic stroke. Here we report that adrenergic receptor (AdR) antagonism accelerates normalization of extracellular K+, resulting in faster recovery of neural activity after photothrombotic stroke. Remarkably, systemic adrenergic blockade before or after stroke facilitated functional motor recovery and reduced infarct volume, paralleling the preservation of the water channel aquaporin-4 in astrocytes. Our observations suggest that AdR blockers promote cerebrospinal fluid exchange and rapid extracellular K+ clearance, representing a potent potential intervention for acute stroke.

Original languageEnglish
Pages (from-to)11010-11019
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Volume166
Issue number22
DOIs
Publication statusPublished - 2019 May 28

Fingerprint

Adrenergic Receptors
Stroke
Aquaporin 4
Aquaporins
Adrenergic Antagonists
Astrocytes
Adrenergic Agents
Cerebrospinal Fluid
Homeostasis
Ischemia
Neuroprotection
Brain
Therapeutics

Keywords

  • Adrenergic receptor
  • AQP4
  • Aquaporin-4
  • Extracellular potassium
  • Ion
  • Photothrombotic stroke

ASJC Scopus subject areas

  • General

Cite this

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. / Monai, Hiromu; Wang, Xiaowen; Yahagi, Kazuko; Lou, Nanhong; Mestre, Humberto; Xu, Qiwu; Abe, Yoichiro; Yasui, Masato; Iwai, Youichi; Nedergaard, Maiken; Hirase, Hajime.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 166, No. 22, 28.05.2019, p. 11010-11019.

Research output: Contribution to journal › Article

Monai, H, Wang, X, Yahagi, K, Lou, N, Mestre, H, Xu, Q, Abe, Y, Yasui, M, Iwai, Y, Nedergaard, M & Hirase, H 2019, 'Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke', Proceedings of the National Academy of Sciences of the United States of America, vol. 166, no. 22, pp. 11010-11019. https://doi.org/10.1073/pnas.1817347116
Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q et al. Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 2019 May 28;166(22):11010-11019. https://doi.org/10.1073/pnas.1817347116
Monai, Hiromu ; Wang, Xiaowen ; Yahagi, Kazuko ; Lou, Nanhong ; Mestre, Humberto ; Xu, Qiwu ; Abe, Yoichiro ; Yasui, Masato ; Iwai, Youichi ; Nedergaard, Maiken ; Hirase, Hajime. / Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 166, No. 22. pp. 11010-11019.
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