Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity

Jiatu Li, Taisei Kaku, Yuki Tokura, Ko Matsukawa, Kenta Homma, Taihei Nishimoto, Yuki Hiruta, Aya Mizutani Akimoto, Kenichi Nagase, Hideko Kanazawa, Seimei Shiratori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cell manipulation technique using thermoresponsive polymers is currently attracting much attention for applications in the medical field. To achieve arbitrary and accurate cell control, it is necessary to intensely research fibronectin behavior. A smart surface, which has thermoresponsive wettability and which can adsorb or desorb fibronectin repeatedly without the presence of cells, was fabricated by an electrospinning method. The fabricated coating changed its structure as the temperature was changed, and this transformation could substitute for the pulling force generated by the cytoskeletal contraction of cells. Moreover, a coated quartz crystal microbalance was able to detect the fibronectin behavior as frequency shifts, which could be used in the estimation of the mass shift with the aid of suitable equations. This coating and measurement system can contribute greatly not only to the development in the medical field centered on biomaterial manipulation technologies, but also to the improvement of medical instruments.

Original languageEnglish
Pages (from-to)1748-1755
Number of pages8
JournalBiomacromolecules
Volume20
Issue number4
DOIs
Publication statusPublished - 2019 Apr 8

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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