Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae

Rie Isozumi, Hiroyuki Yoshimine, Miyuki Morozumi, Kimiko Ubukata, Koya Ariyoshi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.

Original languageEnglish
Pages (from-to)1206-1208
Number of pages3
JournalRespirology
Volume14
Issue number8
DOIs
Publication statusPublished - 2009 Nov 1

Keywords

  • 23S rRNA mutation
  • Macrolide resistance
  • Mycoplasma pneumoniae
  • Pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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