Adult neural stem cells and central nervous system repair.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

It has long been believed that the adult mammalian central nervous system does not regenerate after injury. However, recent advances in the field of stem cell biology, including the identification of Musashi-1-positive neural stem cells (NSCs) or NSC-like cells, has provided new insight for the development of novel therapeutic strategies aimed at inducing regeneration in the damaged central nervous system (CNS). The major strategies for inducing regeneration in the damaged CNS can be classified into two subgroups: (1) activation of endogenous neural stem cells and (2) cell transplantation therapies. In this paper, we would like to summarize our recent findings on the functions of the neural RNA-binding protein Musashi-l expressed in neural stem cells in relation to insult-induced neurogenesis, and therapeutic interventions for spinal cord injury, especially focusing on the treatment of spinal cord injury in the acute phase with anti-IL-6 receptor blocking antibody.

Original languageEnglish
Pages (from-to)215-228
Number of pages14
JournalErnst Schering Research Foundation workshop
Issue number60
Publication statusPublished - 2006

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Adult Stem Cells
Neural Stem Cells
Central Nervous System
Spinal Cord Injuries
Regeneration
Interleukin-6 Receptors
Blocking Antibodies
RNA-Binding Proteins
Cell Transplantation
Neurogenesis
Cell- and Tissue-Based Therapy
Cell Biology
Stem Cells
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adult neural stem cells and central nervous system repair. / Okano, Hideyuki.

In: Ernst Schering Research Foundation workshop, No. 60, 2006, p. 215-228.

Research output: Contribution to journalArticle

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