Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood–ocular barrier

Mitsuhito Hirano, Nobuhiro Ohno, Ryuji Tanosaki, Manabu Mochizuki, Kyoko Ohno-Matsui, Kaoru Uchimaru, Arinobu Tojo, Koju Kamoi

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2 Citations (Scopus)


Adult T-cell leukemia–lymphoma (ATL), a rare lymphoid malignancy with a high mortality rate, is caused by the human T-cell leukemia virus type 1. Due to its rarity and poor prognosis, ocular manifestations have yet to be well documented. The mechanisms that underlie ocular involvement in ATL patients, thus, remain poorly understood. We report the first successfully tracked case of ocular inflammation (i.e., uveitis) that developed simultaneously in conjunction with a rapid increase in ATL cells. Our findings for this case suggest that a rapid increase in ATL cells contributed to the disruption of the blood–ocular barrier, which may, thus, represent one mechanism underlying the induction of uveitis in ATL patients. Furthermore, with the development of novel therapies, the longer survival times of ATL patients have raised new issues, such as quality of vision in ATL patients. Hematologists should be aware that a rapid increase in the number of ATL cells may cause adult T-cell leukemia cell-induced uveitis.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalInternational Journal of Hematology
Publication statusAccepted/In press - 2017 Jul 4



  • Adult T-cell leukemia–lymphoma
  • Blood–ocular barrier
  • Human T-cell leukemia virus type 1
  • Ocular inflammation
  • Uveitis

ASJC Scopus subject areas

  • Hematology

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